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TEER
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March 03, 2023
Introduction
In the process of ‘cell cycle’, cells grow and divide into two genetically identical daughter cells. It is regulated by a complex signaling pathway which keeps cell homeostasis by regulating cell division and DNA duplication1. On the other hand, because cancer cells grow and divide indefinitely out of cell cycle control, anti-mitotic drugs are used to suppress abnormal proliferation...more -
March 01, 2023
Introduction
Cytotoxicity refers to the degree of damage to cells.
caused by chemical substances or physical factors. Measuring it through cytotoxicity assay is essential for drug development and biological research. Cells undergo complex signaling pathways that causes various cell death processes such as apoptosis, necrosis, and necroptosis. However, most cytotoxicity assays...more -
February 24, 2023
EVOM™ AutoLCI Automated Live Cell Imaging System
An integrated live cell monitoring system for stable imaging of suspension cells in immunological research
As white blood cells responsible for immune function are suspension cells that travel along blood vessels, immunology studies often use various suspension cell lines originating from white blood cells. Dealing with suspension cells, unlike adherent cells, slight movement of a plate when locating it on the microscope causes the cells to float. Aside from the problems caused by temperature and CO2 instability, it is in fact not possible to use a traditional microscope to monitor cells in real time. Therefore, in order to stably monitor suspension cells, a live cell imaging device such as EVOM™ AutoLCI that operates...more -
September 13, 2022WPI is very excited to announce our newest product launch and collaboration with MatTek Life Sciences. The companies will offer both MatTek PermaCell Cell Culture Insert Plates and compatible customized World Precision Instruments’ STX HTS EVOM™ Electrode for TEER to their respective customers, available immediately to the life sciences market...more
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July 19, 2022
EVOM™ Manual is WPI's newest instrument to measure Trans Epithelial Electrical Resistance (TEER). Let's look at what comes with the system and how easy it is to setup.
The EVOM™ Manual comes with the following components in the box:
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July 19, 2022
EVOM™ Manual Monitors Cellular Health
WPI's EVOM system is popular in the research community, both in academia and in industry, and it is commonly used for the evaluation of mammalian cellular health by measuring transepithelial/transendothelial electrical resistance (TEER or TER) of cellular layers.
EVOM™ Manual is powered by the same EVOM™ technology as older EVOM models (EVOMX, EVOM, EVOM2 and EVOM3). It has advanced features for performing experiments more easily. With the new touchscreen display you can now store data as Microsoft® Excel files on a USB flash drive. Just remove the flash drive with all your recorded data from the EVOM™ Manual and plug it into a computer to access and plot your data...more
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July 12, 2022
WPI’s EVOM™ technology is the gold standard for delivering stable and repeatable Trans Epithelial Electrical Resistance (TEER) measurements. Here are nine reasons to trust the new EVOM Manual TEER Meter for qualitatively measuring cell monolayer health and quantitatively measuring cell confluence.
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May 31, 2022
WPI’s EVOM™ Manual is the gold standard for delivering stable and repeatable Trans Epithelial Electrical Resistance (TEER) measurements. The EVOM™ Manual qualitatively measures cell monolayer health and quantitatively measures cell confluence by determining an increase or a plateau in tissue resistance detected using our innovative EVOM™ technology. The main display window has lots of information. Here’s a quick overview. You can download the infographic for a handy reference.
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May 24, 2022
WPI’s EVOM™ Manual is the gold standard for delivering stable and repeatable Trans Epithelial Electrical Resistance (TEER) measurements. The EVOM™ Manual is the newest TEER meter. It qualitatively measures cell monolayer health and quantitatively measures cell confluence by determining an increase or a plateau in tissue resistance detected using our innovative EVOM™ technology. WPI’s state of the art EVOM™ technology provides you with real-time, valuable feedback during experimental measurements.
Electrode options are available for use with the new EVOM™ Manual. Here we will compare these options so you can choose one that’s right for your application.
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May 20, 2022...more
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May 05, 2022
REMS AutoSampler is an automated TEER measurement system that uses a robotic arm to make measurements in 24- and 96-well plates. This article details how to upgrade the software for a REMS system.
Considerations Before You Begin
The first consideration is the hardware in your REMS system and the software version you are running.
Systems Older than 2014
- If your system was purchased before 2014, the REMS will have a PCI6023 data card, and you may only upgrade to the REMS4 software. See below for instructions on verifying your software version.
- To upgrade to the current version of the REMS software (REMS6.02), a unit purchase before 2014 will need a PCI6220 data card. You may purchase the upgrade kit (WPI# 300555), which includes the board/data card (for example, NI PCI6220), a new interface cable and software version 6.0.2.
In addition, you need a newer computer with free PCI slot. WPI’s current REMS computer...more
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April 20, 2021
by Benjamin Dubansky, PhD, Animal Physiologist/Researcher
The EVOM is a special kind of voltmeter for measuring electrical properties across a layer of cells in culture or a biological membrane. Here's a few things I like about the new EVOM3.
There's a couple things I like about the EVOM3 better than the older models.
- You can charge it. These ones had batteries which are fine, and they had a power plug. But when you use the power plug, you get a little bit electrical noise, and the signal's not quite as stable. When you have a good battery in here, the charge lasts for quite some time. It charges pretty quickly. You...more
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April 20, 2021
by Benjamin Dubansky, PhD, Animal Physiologist/Researcher
An Ussing Chamber is used when performing barrier studies across an excised epithelial tissue. Similar measurements can be made in well plates using an EVOM series TEER Measurement Meter, which is used for epithelial tissue that is grown to confluence in a cell culture well. While EVOM measurements are only qualitative, your throughput is much greater with an EVOM3. The EVOMs are portable and much more economical than an Ussing Chamber. Here Ben Dubansky, PhD explains the differences between EVOMs and Ussing chambers.
The EVOM is a special kind of voltmeter for measuring electrical properties across a layer of cells in culture or a biological membrane. We are measuring TEER (TER) - Transepithelial Electrical Resistance. The EVOM3...more
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April 19, 2021
by Benjamin Dubansky, PhD, Animal Physiologist/Researcher
The EVOM is a special kind of voltmeter for measuring electrical properties across a layer of cells in culture or a biological membrane. It is the most commonly used commercial system for measuring across a layer of cultured cells. We are measuring TEER (TER) - Transepithelial Electrical Resistance. The EVOM3 allows us to zoom in and measure either resistance or voltage across these membranes or cells in culture.
Why was it invented?
The EVOM (Epithelial Volt Ohm Meter) was designed in the 80’s. It was invented back when multiwell culture plates were first introduced...more
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May 15, 2020
The NEW EVOM3 Epithelial Volt/Ohm Meter delivers improved workflow efficiency, increased stability and more repeatable measurements than traditional Trans Epithelial Electrical Resistance (TEER) meters. Here are seven things you will love about the new EVOM3.
1. It has an intuitive Touchscreen Display
Providing users with vital feedback during experimental measurements, the EVOM3’s large touch screen offers a range of informational views. The new graphical displays for trend analysis and measurement values helps you deliver a simple, stepwise methodology during experimental measurements. The touch screen interface...more