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Laboratory Equipment Blog

  1. Genetic Transfer (viral or non-viral vector) Using Microprocessor-Controlled Injector
    March 02, 2020
    With the first approved human gene therapy trial in 19891 (Rosenberg, et.al.), gene therapy has come a long way in modern medicine and is making inroads in clinics and the market in general.2,3 2017 was an important year for gene therapy when Luxurna, the first human gene therapy drug for an inherited retinal dystrophy, was approved by Food and Drug Administration (USA).4 Now several drugs are undergoing clinical trials. With an estimated $11 billion (USD) market in the next 10 years, both clinical trials and the pharmaceutical industry are expected to benefit immensely from gene therapy.5 With improved use of viral vectors (Adeno-associated virus (AAV), adenovirus, lentivirus, retrovirus, HSV) or non-viral vectors, research and clinical trials on the development of therapeutic genes have witnessed great success. Viral vectors
  2. Benefits of Nitric Oxide Detection using the WPI Free Radical Analyzer
    February 25, 2020
    Nitric oxide (NO) is an essential signaling molecule and is known to play a significant role in a multitude of physiological systems including the central nervous system (CNS), the cardiovascular system, the gastrointestinal tract, the immune system, and the renal system. 1-5 However, being highly reactive, detection and quantification of NO is very difficult.6,7 It requires a sensor that is sensitive, selective to NO, and easy to calibrate. WPI’s Free Radical Analyzer (4-channel TBR4100  and single-channel TBR1025) and the LabTrax Data Acquisition System with the options o
  3. New Technology Makes Microinjection More Reliable, Repeatable and Affordable
    January 24, 2020
    Microinjection is the process of transferring genetic materials into a living cell using glass micropipettes or metal microinjection needles. Glass micropipettes can be of various sizes with tip diameters ranging from 0.1 to 10 µm. DNA or RNA is injected directly into the cell’s nucleus. Microinjection has been successfully used with large frog eggs, mammalian cells, mammalian embryos, plants and tissues. Microinjection has been expensive, can be a slow process and requires skilled personnel, but new technologies are making it even more reliable, repeatable and affordable. Pronuclear injection, inserting DNA or RNA into the nucleus of a fertilized oocyte to create transgenic organisms, lets researchers study the role of particular genes. This horizontal gene transfer can insert genetic material from the same species or a
  4. Advanced Flowcell Cleaning for Liquid Waveguide Capillary Cells
    December 20, 2019
    The purpose of this article is to describe a new cleaning procedure for thoroughly cleaning WPI flowcells, including Liquid Waveguide Capillary Cells (LWCCs), UltraPath flowcells and optical cuvettes. The image (right) shows a 3000 series LWCC with a MiniStar pump and the LWCC injection system placed on top of it.  Preparation of Chemicals All chemical reagents should be of at least ACS-Grade, preferably HPLC-Grade. This procedure involves the use of caustic and flammable reagents. Consult the manufacturer’s MSDS for necessary safety precautions. Cleaning Solution #1: 0.5M Potassium Hydroxide in 100% Ethanol (e.g.: 7 g KOH in 250mL EtOH). After thoroughly mixing, filter the solution through a 20µm pore size filter. Cleaning Solution #2: 100% Methanol, HPLC grade Cleaning So
  5. OEM Optical Fiber Manufacture - Your OEM Partner for Qualified Fiber, Assemblies, Probes and Flow Cells
    November 11, 2019
    WPI's Photonics Center of Excellence in Friedberg, Germany provides a full range of optical components and optical sensing solutions, including proprietary multimode silica qualified fiber, optical assemblies and sub-assemblies serving
  6. Meet Our Researchers
    September 12, 2019
    Researchers around the globe trust WPI products. Here are a few who have shared glimpses into their research areas.
  7. Benefits of Black Coated Instruments
    September 06, 2019
    Benefits of black coated surgical instruments Black coated surgical instruments are not only visually more attractive than the stainless-steel ones, there are several other benefits as provided below: -        Non reflective surface reduces eye-fatigue   -        Has prolonged life -        Up to 10 times harder than stainless steel -        60% lower wear rate than stainless steel -        Corrosion resistant due to oxidized aluminum coating -        Anti-allergic due to the absence of Chromium and Nickel coating  -        Easy to clean Making of the black coating instruments The black coatings are created by applying a layer of Titanium Aluminum Nitrate (TiAIN) to the instrument, using an environmentally friendly Physical Vapor Deposition (PVD) process. In this process Titanium and Aluminum are magnetron-sputtered onto the substrate in a vacuum chamber. The metal particles of the ta
  8. WPI's NanoFil: Injection of Sub-Microliter Volumes in Animal Research
    August 21, 2019
    Are you looking for a microliter or sub-microliter and high precision syringe that holds needles as small as 36 gauge (G), in addition to having the capability to connect to quartz tubing? WPI’s NanoFil is the answer. We offer NanoFil syringes with NanoFil needles or the option to connect the NanoFil syringe to quartz tubing to use in research studies, mainly involving sub-microliter volume injections into animal tissues. Why Select WPI’s NanoFil (Syringe and Needle) System? Low Dead Volume The dead volume of NanoFil's is minute or neglig
  9. Non-Reflective Instruments Minimize Glare when Working under Lights
    August 09, 2019
    Whether you are working with your surgical instruments under bright lights or using a microscope, non-reflective black surgical instruments offer a distinct advantage. The titanium coating not only hardens and protects the cutting edge, but it also minimizes reflection from the surface of your instruments while you are working. They are corrosion resistant and biocompatible.  See Selection
  10. Researcher Shares Video of MICRO-ePORE™ Assisted Cell Penetration
    August 02, 2019
    The new WPI MICRO-ePORE™ pinpoint cell penetrator is a simple and versatile system that can be used to facilitate microinjection of a diverse array of compounds and biomolecules into oocytes and pre-implantation stage mammalian embryos. Patent pending Flutter Electrode Technology assists in small, clean, precise membrane penetration without tearing or damaging the membrane. It results in substantially increased viability of embryos. In this quick video, Dr. Pelczar from the Center for Transgenic Models in Switzerland demonstrates the ease of cell penetration using the new MICRO-ePORE™. 
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