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Electrophysiology

  1. CardioPhys ECG is Perfect for Affordable Cardiotoxicity Testing in Small Animals
    May 18, 2020
    [by Mikaël Berrou] CardioPhys™ and Cardiotoxicity When a new drug is discovered with an effect against a pathology, a natural public demand would ask to administrate it immediately. Although the new drug may be beneficial in many aspects, that new molecule could potentially have side effects that need to be evaluated. The most important potential side effect is cardiotoxicity. What is Cardiotoxicity? Cardiotoxicity is the damage to the heart by harmful chemicals (www.nccn.org/patients/resources/life_with_cancer/managing_symptoms/cardiac_toxicity.aspx), and its evaluation ha
  2. Setting Up the DUO773 Electrometer
    June 19, 2019
    For intracellular dual or differential studies, WPI's Duo773 has separate negative capacity controls and built-in active filtering that allows the precise balancing of time constants for artifact-free differential measurement. It comes complete with two probe headstages, 1015Ω and 1011Ω probes to monitor signals from ion-specific micro-electrodes as well as KCl-filled electrodes. Jim shows you how to safely unpack and properly setup your new Duo773. More Info
  3. Using a DAM50 for EEG Recordings in Rodents
    October 21, 2014
    A low-noise amplifier like the DAM50 is an excellent choice for EEG recording in rodents. WPI's amplifiers were engineered for the bio-medical researcher. While 20-30μV of noise is common in bio-amplifiers, WPI’s DAM series amplifiers generate 0.4μV RMS (root mean squared) at 0.1-100Hz. (That’s equal to about 2μV peak to peak.) This setup shows one way such recordings could be made. The RC1 electrode works well for rats, and the EP1 is more suitable for mouse cranial application. For this application, you will need the following equipment: (1) DAM50 amplifier (1) MD4R micromanipulator (2) M3301EH electrode holders (2) Profile A single tungsten metal electrodes (1) M10 stand (1) 5052 steel base plate (1) 5470 cable (1) electrode (RC1 or EP1) Rat Cranial Applications The RC1 electrode comes with a 4' unterminated wire attached. That needs to be soldered to the green-white ground wire of the 5470 cable. The red wire from the 5
  4. How to Use an EndOhm Chamber with an EVOM2
    September 03, 2013
    The EVOM2 measures trans epithelial electrical resistance (TEER) in tissue culture research. The EndOhm series of chambers for the EVOM2 are designed to accurately measure trans endothelial electrical resistance. Learn how to setup your EndOhm Chamber with an EVOM2 Epithelial Volt Ohm Meter. See how to equilibrate the sensors when taking a voltage measurement. And, learn how to take resistance and voltage measurements.  
  5. Metal Electrode Selection Guide for Profile B
    May 01, 2013
    Profile B Microelectrodes These electrodes are sold in packages of 10. Tungsten Profile B Comparison Chart, 76 mm long, 0.216 mm shaft Order code Length  InsulationThickness ShaftDiameter NominalImpedance±20% TipDiameter  Typical Use TST33C05KT 76mm 3µm 0.216 mm 0.5 MΩ 1µ Stereotrode / Bipolar, differential measurements - extra fine TST33C10KT-B 76mm  3µm 0.216 mm 1.0 MΩ  1µ Stereotrode / Bipolar, differential measurements - extra fine. Blunt tip. TST33C10KTH 76mm  3µm 0.216 mm 1.0 MΩ  1µ Stereotrode / Bipolar, differential measurements - extra fine. Heat treated. TST33C20KT 76mm 3µm  0.216 mm 2.0 MΩ 1µ Stereotrode / Bipolar, differential measurements - extra fine Tungsten Profile B Comparison Chart, 76 mm long, 0.356 mm shaft Order code Length  InsulationThickness ShaftDiameter NominalImpedance±20%
  6. Stimulator/Isolator Comparison Chart
    April 30, 2013
    WPI offers a range of isolators and stimulators. Use the chart below to find the components that are compatible. Isolators  Features Input Output Compatible Stimulators DLS100
  7. WPI's Low-Noise Amplifiers Outperform Cheap Imitations
    April 30, 2013
    An amplifier, in simplest terms, is an electronic device that magnifies an input signal. However, the way an amplifier is designed to handle noise and bandwidth limitations greatly affects the quality and sustainability of the final output signal. Defining Terms To knowledgeably discuss amplifiers, let’s define a few terms. Gain – The gain is the multiplier defining how much the amplitude of an input signal is increased. A signal with an X1 gain is not amplified. An X10 gain produces an output signal ten times greater than the input signal. Noise – Any unwanted signal fluctuations are called noise. While noise can also result from external sources, for the purpose of this discussion, we are primarily concerned with the noise resulting from the inner workings of the electronic device, our amplifier. This
  8. Compare Dri-Ref Reference Electrodes
    April 29, 2013
    Dri-Ref™ reference electrodes were developed by WPI to have extremely low electrolyte leakage properties, hence the name “Dri-Ref.” In addition to this key feature, these electrodes exhibit stable and reproducible potential and low resistance. Stored in KCl when not in use, they have a long life expectancy. Low leakage is achieved by using KONBO™, a product combining modern ceramic and conductive polymer technology, as the liquid junction. Electrode resistance is low, an important consideration when making low-noise measurements. Although the internal filling solution contains KCI, the low fluid leakage means Dri-Ref may be used in combination with ion selective electrodes, including those for K+ and Cl-, without significant contamination from the reference electrode. The Dri-Ref electrodes are che
  9. Ag/AgCl Half Cells
    April 29, 2013
    WPI's silver-silver chloride half cells are new, improved sintered pellets with lower resistance and high strength. They are stable and well-balanced in the presence of current. These small and inexpensive half-cells are easy to work with as bath electrodes.   RC1 /RC1T RC2
  10. Metal Microelectrodes Basics
    April 26, 2013
    Superior microelectrodes for outstanding extracellular recording — tungsten, iridium, platinum-iridium, and Elgiloy® Click here to view the Metal Microelectrode Selection Guide Types of Metal Electrodes WPI offers a large variety of metal electrodes and they come in three basic styles (profiles). The selection guide that follows references the three electrode profiles. In addition, concentric bipolar electrodes are also discussed, as well as some of the options offered for the metal electrodes. NOTE: The electrode diagrams below are not shown to scale.  Profile A  
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