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April 13, 2023World Precision Instruments (WPI) is excited to launch the newest member to its EVOM™ family of products, the EVOM™ Auto. The new EVOM™ Auto enables rapid and reproducible measurements of Transepithelial Electrical Resistance (TEER), a well-established and widely accepted method of evaluating epithelial and endothelial cells and tissues, in vitro. WPI’s EVOM™ Auto combines TEER technology with high throughput screening capabilities, resulting in the automated measurement of resistance in 96-well cell culture plates. This data gives scientists and drug discovery laboratories insights into tissue and monolayer barrier integrity, cell permeability, cell confluency, and can readout the critical physiology of barrier tissues such as the blood-brain barrier, the gastrointestinal tract, the lung, and the skin. ...more
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April 13, 2023
The EVOM™ Auto automates measurements of TEER in epithelial or endothelial monolayers cultured on high throughput screening 96-well plates utilizing our innovative EVOM™ technology, qualitatively measuring cell monolayer health and quantitatively measuring cell confluence by determining an increase or a plateau in tissue resistance.
The video below shows you how to download and how to delete a data file EVOM™ Auto:
Once a data acquisition run is complete, the data may be exported. This process exports all the runs performed on a plate into a downloadable, comma-delimited (CSV) file which can be read by Microsoft® Excel or Google Sheets. The downloaded file is immediately available.
To download a data file, press the Download...more
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April 11, 2023
The EVOM™ Auto automates measurements of TEER in epithelial or endothelial monolayers cultured on high throughput screening 96-well plates utilizing our innovative EVOM™ technology, qualitatively measuring cell monolayer health and quantitatively measuring cell confluence by determining an increase or a plateau in tissue resistance.
The video below shows you how to run an experiment on the EVOM™ Auto:
To begin running an experiment, select Experiment from the main menu. Then, select the Plate Name drop-down in the Details area on the right side of the screen. Choose from the list of existing plates or select New Plate to define a new plate. Enter the name for the plate...more
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April 06, 2023
The EVOM™ Auto automates measurements of TEER in epithelial or endothelial monolayers cultured on high throughput screening 96-well plates utilizing our innovative EVOM™ technology, qualitatively measuring cell monolayer health and quantitatively measuring cell confluence by determining an increase or a plateau in tissue resistance.
The video below shows you the features of the homepage on the EVOM™ Auto:
Introducing the Home Screen – Tips for Getting Started
Select a Plate Brand
The Electrode Array is configured to support 96-well plates. Three different brands of plates are supported:- C96_HTC – Corning 96 Well Plate
- M96_HTC – Milipore 96 Well Plate
- O96_HTC...more
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April 04, 2023
Optimized, in vitro workflow to identify compounds with vasoactive properties
In vitro models have employed two common methods to quantify changes in endothelial barrier integrity: transepithelial/transendothelial electrical resistance (TEER) and tracer compound permeability.1 TEER is a non-invasive method that quantifies changes in electrical conductance to measure confluency and barrier integrity. Tracer compound permeability uses molecules of defined molecular weights to measure the size exclusion capacity of cell barriers (e.g., 4 kDa FITC-dextran or FD4).1 Using the EVOM™ Manual (EVOM-MT-03-01) with the EndOhm TEER electrode and cell culture permeable supports, this application note describes how to non-invasively evaluate endothelial barrier integrity after cytokine treatment and provides a method to identify vasoactive compounds that have the potential to induce vascular injury. Tracer compound permeability studies...more
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March 31, 2023
On the new WPI website, multiple related products may be grouped together to make them easier to compare.
The price range of all the options is shown at the top left corner of the product page.
To make a selection easier, a grid in the Details area (below the images) lists the details of all the products listed on the page, including the order code.
Click Choose an Option to select the model you want. If the option price deviates from the default selection, you see the additional cost listed next to the option. In this example in the video, the curved scissors cost $4 more than the straight, and the German steel scissors cost $43 more.
When you select your option, the price of your selection shows at the top of the screen.
Select the quantity you need and click the Add to Cart button. The shopping cart reflects the price of your option.
If you have any...more -
March 29, 2023
WPI’s new web is now live, and we want to help you get started.
When you create an account, you can:
- See your advanced pricing
- Check out faster without having to enter all your data each time
- Take control of your account
- Update your contact information
- Manage orders
- Maintain a wish list
- Track your order history
- And more!
Creating an account is...more -
March 27, 2023
WPI’s new web is now live, and we want to help you get started.
WPI is required to collect taxes in most states. If you are tax-exempt and operate in one of those states, you need to submit proper documentation before we can process your orders without tax. To apply for tax-exempt status:- Create an account by clicking on the account icon in the upper right corner of the screen and following the prompts. Navigate to the Tax Exempt Application at /tax-exempt-application. Enter your contact information and upload your current Sales Tax Certificate.
- Our customer service team will verify your tax status and let you know when your tax-free account is ready. This takes less than one business day.
- Then, you can place orders online, and we will not collect taxes.
If you need to expedite the process...more
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March 16, 2023
World Precision Instruments' (WPI) legacy Robotic Epithelial Measurement System (REMS) and the new advanced, upgraded version of REMS, EVOM™ Auto, are high-throughput, automated transepithelial/transendothelial electrical resistance (TEER) measurement systems. These robotic systems, combined with EVOM™ technology, expedite TEER measurements.
A 96-well plate can be read within a few minutes using an automated TEER measurement system versus using a manual TEER measurement system, which can take up to 90 minutes to read a single 96-well plate. Manual systems require a user to move the electrode from one well to another and perform the rinsing in between, if needed. (Rinsing of the electrode while reading through a number of samples helps to prevent sample cross-contamination.) As automated systems measurements and rinsing are controlled by robotics, manual handling time is eliminated. Additionally, automated systems offer better measurement...more