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Blog
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May 07, 2024
Cell therapies have emerged as a promising approach for treating various medical conditions, offering the potential for regenerating damaged tissues, restoring normal cellular function, or even acting as cytotoxic cells that target and destroy diseased cells such as cancer cells. As the field of cell-based therapeutics and regenerative medicine continues to advance, ensuring the quality and safety of cell-based therapies is of paramount importance. Quality control measures play a critical role in the manufacturing process of cell therapies, with trans-epithelial electrical resistance (TEER) emerging as a valuable tool for assessing the integrity and functionality of cells used in these therapies. Here, we highlight the use of TEER for quality control of Retinal Pigment Epithelial (RPE) cells, a promising cell therapy for degenerative retinal diseases1...more
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May 07, 2024
Cell therapies have revolutionized the field of regenerative medicine, offering promising treatments for a variety of medical conditions. Maintaining the safety, efficacy, and consistency of cell-based therapies is paramount for their successful application in clinical settings. Quality control measures play a vital role in evaluating the quality of these therapies, from development to administration. This article explores the current approaches to quality control in cell therapies, including the utilization of functional measurement techniques such as transepithelial electrical resistance (TEER), to ensure the quality and safety of these promising treatments...more
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May 03, 2024
Transepithelial electrical resistance (TEER) has emerged as a powerful tool in ophthalmology research and has become a standard method for study of retinal pigment epithelial (RPE) cell biology and the development of these cells as a therapeutic for retinal diseases such as Age-Related Macular Degeneration (AMD). The application of TEER in assessing the barrier function and integrity of RPE cell layers has significantly advanced our understanding of retinal diseases and paved the way for innovative therapeutic interventions including some of the most promising cell therapies to date. This article explores the use of TEER in ophthalmology research, with a focus on studies utilizing RPE cells for both research and clinical applications...more
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April 30, 2024
Join WPI May 5 - 9 in Seattle, Wash., for a showcase of new research and the opportunity to network with colleagues and industry thought-leaders...more
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April 09, 2024
It has been found that transgenesis of vectors using Tol2 or other transposon-based systems promote stable expression. A standard pressure-based microinjection approach presents greater reliability, precision, and overall control when delivering material to embryos, often preferred over electroporation in zebrafish studies...more
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March 20, 2024
World Precision Instruments (WPI) is pleased to announce their strategic partnership with TotalLab, paving the way for the integration of 21 CFR Part 11 compliance into its esteemed EVOM family of products...more
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February 22, 2024
EVOM™ Auto, with both 24 and 96 HTS multiwell plate capability, is a high throughput screening (HTS) platform offering fast, noninvasive sample scanning by comparing electrical resistance measurements (transepithelial/transendothelial electrical resistance: TEER). TEER measurement experiments are simple to set up and less time consuming than more complex molecular studies. TEER measurement can be used as the primary scanning method to identify any physiological changes that can then be further evaluated by other methods. EVOM™ Auto can capture TEER measurements in 24 and 96 HTS multiwell plates from Corning, Millipore, or MatTek. The sample preparation time in these HTS plates is efficient, allowing for fast, multi-channel pipetting options.
The EVOM™ Auto autosampler ships with a red electrode array lock in place to prevent the electrode array connection port from moving during transit. Here you can see how to easily remove it without damaging the lock or the autosampler...more
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February 19, 2024
Below are some popular pullers from WPI, including Sutter pullers. Here we compare them so you can choose a system that is best suited for your application...more
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February 16, 2024
The WPSS01 skin stapler is an affordable, reliable solution for veterinary wound closures. A skin stapler is designed for the efficient closure of surgical incisions or wounds by applying surgical staples to the skin, reducing surgery time and time under anesthesia. Each disposable skin staple cassette contains at least thirty-five (35) 316L stainless steel staples.
Each reusable skin stapler handle is provided sterile with one disposable staple cassette already loaded into the handle. Discard the disposable staple cassette after the procedure. The reusable handle may be cleaned and resterilized (autoclave, EO) for subsequent procedures and will effectively deploy at least twenty (20) disposable staple cassettes and withstand at least twenty (20) autoclave cycles...more
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February 06, 2024
Surgical forceps are available in several different grades, including disposable, standard stainless steel, German steel, Swiss made, and titanium. Your choice of instrument grade will depend on your requirements and your budget. Here are some considerations to help you make an informed decision...more