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LabTrax 8/16 hardware combined with MDAC software is an excellent choice for WPI's SI-H line of muscle physiology products like the SI-MT Muscle Platform, SI-CTS Cell Tester and SI-HTB Horizontal Tissue Baths. This data acquisition system is ideal for testing physiological characteristics like the contractile and elastic properties of different tissues in various conditions like isometric, anisometric or isotonic states. This data acquisition system was designed with the muscle researcher in mind, because the knowledge of physiological characteristics of muscles is critical when quantifying the beneficial or adverse effects of a stimulus (like a pharmaceutical drug) on muscle function in pre-clinical studies.

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Stretch receptors are specialized fibers that are in parallel to the fibers in muscle. The receptors stretch as the muscle is lengthened, and they generate action potentials. The frequency of these action potentials is proportional to the length of muscle stretch and the position of the muscle. Through sensory nerve fibers from the stretch receptors, the action potentials and their frequency provide feedback to the central nervous system that will modulate reflex responses and motor control of the muscle.

Setup

For these studies, the whole muscle and the nerve that innervates it are isolated from the organism. A muscle and its nerve, like the Soleus, is isolated and placed in the cuvette of an SI-MT or SI-HTB muscle research system. The muscle is positioned so that the myoneural junction (the place where the nerve innervates the muscle) is on the top side of the muscle. The ends of...more