Epithelial Volt/Ohm (TEER) Meter

$2,122.00
Order code
VAR-2754

Non-destructively test for epithelial monolayer confluence in 2D cell cultures

  • Measures trans-epithelial electrical resistance or trans-epithelilal voltage
  • Compatible with 12 and 24 well culture plate systems out of the box
  • Includes industry standard STX2 hand held “chopstick” electrodes
  • Analog output for recording resistance or voltage measurements
  • Auto ranging from 0-10 KΩ
  • Battery powered
  • Manual TEER measurement of epithelial cells in 6, 12, 24 and 96* well plates
  • BNC output for data acquisition system
  • Compatible with EndOhm chambers
  • *96-well plate measurement requires an STX100 series electrode.

Click here to view the current Data Sheet.   

Options

Part # Voltmeter Electrode Charger (800496)

Battery (91736)

1 k-Ω Test Resistor (91750)
EVOM2 0-10 kΩ Range Epithelial Volt/Ohm Meter

STX2

(Basic Electrode)

Yes Yes (Installed) Yes
91799 0-10 kΩ Range Epithelial Volt/Ohm Meter

STX3

(Basic Adjustable Gap Electrode)

Yes Yes (Installed) Yes
300523 0-100 kΩ Range Epithelial Volt/Ohm Meter

STX2

(Basic Electrode)

Yes Yes (Installed) Yes

Benefits

  • You can verify performance and calibrate the meter for TEER function using provided test resistor
  • Battery powered meter is portable
  • A variety of accessory electrodes are available for measuring TEER in 6- and 96-well fixed (HTS) and removable well culture systems (See STX100 series and Endohm electrodes)

Applications

  • TEER and trans-epithelial voltage measurements in 2D cell cultures

Making TEER Measurements to Determine Cellular Confluence

The EVOM was the first instrument designed specifically to perform routine Trans Epithelial Electrical Resistance (TEER) measurement in tissue culture research. EVOM2 is the next generation, redesigned for ease of use. The EVOM2 not only qualitatively measures cell monolayer health, but also quantitatively measures cellular confluence. The unique electronic circuit of the EVOM2™ and the included STX2  electrode detect the confluence of the cellular monolayer. When combined with WPI’s Endohm chamber, the EVOM2 can also be used to perform more accurate quantitative measurements or lower resistance measurements like transendothelial electrical resistance measurements. 

Isolated battery power for 10 hours of use

The isolated power source of the EVOM2™ was specifically designed to avoid adverse effects on tissue and the formation of electrode metal deposits, even when it is plugged into a standard wall outlet. Now, the EVOM2™ is always on when you need it. In addition, its rechargeable battery allows up to 10 hours of mobile use.

Accurate reading every time

The four-and-a-half digit readout provides a range of 1-9,999 Ω. The included test electrode lets you calibrate the resistance measurements for an accurate reading every time, and the voltage meter never needs calibration. An analog BNC output is standard with the EVOM2™, providing an output port for recording data or remote display of the EVOM2™ output.

Electrode pair to measure voltage, pass current

EVOM2™ comes complete with the popular STX2 “chopstick” electrodes, 4 mm wide and 1 mm thick. Each stick of the electrode pair contains a silver/silver-chloride pellet for measuring voltage and a silver electrode for passing current. The small size of each electrode is designed to facilitate placement of the electrodes into a variety of standard cell culture wells. 

    STX2      STX3

       STX2              STX3

 

More Information about the EVOM2

VIDEO: Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers

 

Videos

See how to use and EndOhm chamber with an EVOM2 meter. 

In this video Mike shows you how to equilibrate your STX electrodes.

In this video, you can learn how to test your EVOM2.

Membrane Voltage Range +/-200 mv
Resolution 0.1 mV
Resistance Range 0 to 9999 Ω *   
Resistance Resolution 1 Ω
AC Square Wave Current +/- 10uA nominal at 12.5 Hz
Power Internal rechargeable 6V NiMH
2700 mAH batter with external
12VDC Supply for recharging
Nomimal Battery Run Time 10 hours
BNC Output  

1-10 V (1 mV/Ω)

 

Dimensions 19x11x6 cm (7.25x4.25x2.30")
Weight 1.4 kg (3 lb.)
Electrode Connection RJ-11 connector (telephone style)
Test Resistor External, 1000 Ω 
Environmental Range 10-38°C (50-100°F)
0-90% non-condensing relative humidity
Power Supply Universal 100-240 VAC, 120 VDC (5.5 x 2.5mm barrel positive tip), 850 mA

* 300523 is the part number for the EVOM2 with 10X the resistance range. Note that display on this unit reads in KΩ, and the display on the standard EVOM2 read Ω.

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Close, T. E., Cepinskas, G., Omatsu, T., Rose, K. L., Summers, K., Patterson, E. K., & Fraser, D. D. (2013). Diabetic Ketoacidosis Elicits Systemic Inflammation Associated with Cerebrovascular Endothelial Cell Dysfunction. Microcirculation, 20(6), 534–543. https://doi.org/10.1111/micc.12053

Lei, Y., Stamer, W. D., Wu, J., & Sun, X. (2013). Oxidative stress impact on barrier function of porcine angular aqueous plexus cell monolayers. Investigative Ophthalmology & Visual Science, 54(7), 4827–4835. https://doi.org/10.1167/iovs.12-11435

Guzman-Aranguez, A., Woodward, A. M., Pintor, J., & Argüeso, P. (2012). Targeted disruption of core 1 β1,3-galactosyltransferase (C1galt1) induces apical endocytic trafficking in human corneal keratinocytes. PloS One, 7(5), e36628. https://doi.org/10.1371/journal.pone.0036628

Booth, R., & Kim, H. (2012). Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB). Lab on a Chip, 12(10), 1784. https://doi.org/10.1039/c2lc40094d

Schmedt, T., Chen, Y., Nguyen, T. T., Li, S., Bonanno, J. A., Jurkunas, U. V., … Giasson, C. (2012). Telomerase Immortalization of Human Corneal Endothelial Cells Yields Functional Hexagonal Monolayers. PLoS ONE, 7(12), e51427. https://doi.org/10.1371/journal.pone.0051427

Strengert, M., & Knaus, U. G. (2011). Analysis of Epithelial Barrier Integrity in Polarized Lung Epithelial Cells. In Methods in molecular biology (Clifton, N.J.) (Vol. 763, pp. 195–206). https://doi.org/10.1007/978-1-61779-191-8_13

Alhamoruni, A., Lee, A. C., Wright, K. L., Larvin, M., & O’Sullivan, S. E. (2010). Pharmacological Effects of Cannabinoids on the Caco-2 Cell Culture Model of Intestinal Permeability. Journal of Pharmacology and Experimental Therapeutics, 335(1).

Hellinger, É., Bakk, M. L., Pócza, P., Tihanyi, K., & Vastag, M. (2010). Drug penetration model of vinblastine-treated Caco-2 cultures. European Journal of Pharmaceutical Sciences, 41(1), 96–106. https://doi.org/10.1016/j.ejps.2010.05.015

TORRES, R., PIZARRO, L., CSENDES, A., GARCÍA, C., LAGOS, N., Pasdar, M., … Roskelley, C. (2007). GTX 2/3 EPIMERS PERMEATE THE INTESTINE THROUGH A PARACELLULAR PATHWAY. The Journal of Toxicological Sciences, 32(3), 241–248. https://doi.org/10.2131/jts.32.241

Inglis, V. I., Jones, M. P. J., Tse, A. D. Y., & Easton, A. S. (2004). Neutrophils both reduce and increase permeability in a cell culture model of the blood–brain barrier. Brain Research, 998(2), 218–229. https://doi.org/10.1016/J.BRAINRES.2003.11.031

Campbell, L., Abulrob, A.-N. G., Kandalaft, L. E., Plummer, S., Hollins, A. J., Gibbs, A., & Gumbleton, M. (2003). Constitutive Expression of P-Glycoprotein in Normal Lung Alveolar Epithelium and Functionality in Primary Alveolar Epithelial Cultures. Journal of Pharmacology and Experimental Therapeutics, 304(1).

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Takakuwa, R., Kokai, Y., Kojima, T., Akatsuka, T., Tobioka, H., Sawada, N., & Mori, M. (2000). Uncoupling of Gate and Fence Functions of MDCK Cells by the Actin-Depolymerizing Reagent Mycalolide B. Experimental Cell Research, 257(2), 238–244. https://doi.org/10.1006/excr.2000.4887

Katz, J., Sambandam, V., Wu, J. H., Michalek, S. M., & Balkovetz, D. F. (2000). Characterization of Porphyromonas gingivalis-induced degradation of epithelial cell junctional complexes. Infection and Immunity, 68(3), 1441–1449. https://doi.org/10.1128/IAI.68.3.1441-1449.2000

Wang, G., Zabner, J., Deering, C., Launspach, J., Shao, J., Bodner, M., … McCray, P. B. (2000). Increasing Epithelial Junction Permeability Enhances Gene Transfer to Airway Epithelia In Vivo. American Journal of Respiratory Cell and Molecular Biology, 22(2), 129–138. https://doi.org/10.1165/ajrcmb.22.2.3938

Castro, R., Barlow-Walden, L., Woodson, T., Kerecman, J. D., Zhang, G. H., & Martinez, J. R. (2000). Ion transport in an immortalized rat submandibular cell line SMG-C6. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 225(1), 39–48. https://doi.org/10.1046/J.1525-1373.2000.22505.X

Raimondi, F., Kao, J. P., Fiorentini, C., Fabbri, A., Donelli, G., Gasparini, N., … Fasano, A. (2000). Enterotoxicity and cytotoxicity of Vibrio parahaemolyticus thermostable direct hemolysin in in vitro systems. Infection and Immunity, 68(6), 3180–3185. https://doi.org/10.1128/IAI.68.6.3180-3185.2000

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Blaisdell, C. J., Edmonds, R. D., Wang, X. T., Guggino, S., & Zeitlin, P. L. (2000). pH-regulated chloride secretion in fetal lung epithelia. American Journal of Physiology. Lung Cellular and Molecular Physiology, 278(6), L1248-55. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/10835331

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Hilgendorf, C., Spahn‐Langguth, H., Regårdh, C. G., Lipka, E., Amidon, G. L., & Langguth, P. (2000). Caco‐2 versus Caco‐2/HT29‐MTX Co‐cultured Cell Lines: Permeabilities Via Diffusion, Inside‐ and Outside‐Directed Carrier‐Mediated Transport. Journal of Pharmaceutical Sciences, 89(1), 63–75. https://doi.org/10.1002/(SICI)1520-6017(200001)89:1<63::AID-JPS7>3.0.CO;2-6

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Meerveld, G.-V. B., R, T. K., ル和, & vitro &

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Cellular Confluency of Epithelial Cells

The original EVOM was featured in this application video.

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