Micro Nitric Oxide Sensors

$845.00
Order code
VAR-2968

7 and 30 µm sensors with exceptional performance – ideal for tissues and microvessels

   Don't forget the SNAP!
  • Excellent selectivity to NO
  • Rapid response time
  • Highly sensitive
  • For use with Apollo1000, Apollo4000, TBR4100 and TBR1025
  • Requires cable 91580 (sold separate)
  • Package of 3

Options

Order code Length Tip Diameter Shape
ISO-NOP007 2 mm 7 µm Straight
ISO-NOPF3005 0.5 mm 30 µm  Straight
ISO-NOPF3020 2 mm 30 µm  Straight

 Benefits

  • Linear response over a large dynamic concentration range of NO
  • Dry electrodes require no sleeves or filling solution

Applications

  • NO measurement in microvessels

The ISO-NOP007 has a tip diameter of just 7 microns and a length of 2mm. The response is linear over a wide dynamic concentration range of NO. The design is based on a single carbon fiber coated with WPI's NO-selective membrane. A detection limit of approximately 1 nM NO makes this electrode ideal for use in tissues and microvessels.

The ISO-NOP30 has a tip diameter of 30 microns and is available in two different tip lengths ISO-NOP3020 has tip length of 2 mm, ISO-NO3005 has tip length of 0.5 mm). The response is linear over a wide dynamic concentration range of NO. The design is based on a single carbon fiber coated with WPI's NO-selective membrane. A detection limit of approximately 1 nM NO makes these electrodes ideal for use in tissues and microvessels.

Nitric Oxide Sensor-Simultaneous measurement of force

The response of a 7μm NO sensor (ISO-NOP007) to successive additions of NO (100nM). Inset shows the linearity of the resulting calibration plot.

Nitric Oxide Sensor-changes of NO concentration

Simultaneous measurement of force (top trace) and changes of NO concentration (lower trace) in (A) the rat superior mesenteric artery relaxed with ACh and (B) a small human artery relaxed with ACh and SNAP. In this artery oxyhaemoglobin (oxyHb) partly reversed the increase in NO concentration with only a small change in force. [U. Simonsen, et al., J. Physiol., 1999, 516: 271-282.]

  ISO-NOP007 ISO-NOP3005 ISO-NOP3020
Outside Diameter  7 µm 30 μm 30 µm
Available Length 2 mm  0.5 mm 2 mm
Response Time < 3 seconds  < 3 seconds < 3 seconds
Lowest Detection Limit/Range 0.5 nM  1 nM 1 nM
Nominal Sensitivity-New sensor ≥1 pA/nM  ≥1.4 pA/nM ≥1.5 pA/nM
Baseline Drift none  none  none
Poise Voltage 865 mV  865 mV 865 mV 
Typical Quiescent Baseline Current, 25°C 300 pA  1000 pA 500 pA 
Acceptable Baseline Range 200-1500 pA  150-3500 pA 500-5000 pA 
Polarization Time 1+ hours  1+ hours 1+ hours 



Dantas, B. P. V, Ribeiro, T. P., Assis, V. L., Furtado, F. F., Assis, K. S., Alves, J. S., … Braga, V. A. (2014). Vasorelaxation induced by a new naphthoquinone-oxime is mediated by NO-sGC-cGMP pathway. Molecules (Basel, Switzerland)19(7), 9773–9785. https://doi.org/10.3390/molecules19079773  

More Choices:
  1. Enzol Enzymatic Detergent, 1 Gallon
    Enzol Enzymatic Detergent, 1 Gallon
    7363-4
    $107.00
  2. SNAP Calibration Compound for NO Microsensors
    SNAP Calibration Compound for NO Microsensors
    Multiple SKUs
    $121.00
Frequently Purchased
©Copyright 2020. World Precision Instruments. All rights reserved.

Apply for Tax Exempt Status
WPI collects tax in AL, AZ, CA, CO, CT, DC, FL, GA, IL, IN, MA, ME, MD, MI, MN, MO, NC, NV, NJ, NY, OH, OK, PA, SC, TN, TX, VA, VT, WA and WI