Micro Nitric Oxide Sensors
|Order code||Length||Tip Diameter||Shape|
|ISO-NOP007||2 mm||7 µm||Straight|
|ISO-NOPF3005||0.5 mm||30 µm||Straight|
|ISO-NOPF3020||2 mm||30 µm||Straight|
- Linear response over a large dynamic concentration range of NO
- Dry electrodes require no sleeves or filling solution
- NO measurement in microvessels
The ISO-NOP007 has a tip diameter of just 7 microns and a length of 2mm. The response is linear over a wide dynamic concentration range of NO. The design is based on a single carbon fiber coated with WPI's NO-selective membrane. A detection limit of approximately 1 nM NO makes this electrode ideal for use in tissues and microvessels.
The ISO-NOP30 has a tip diameter of 30 microns and is available in two different tip lengths ISO-NOP3020 has tip length of 2 mm, ISO-NO3005 has tip length of 0.5 mm). The response is linear over a wide dynamic concentration range of NO. The design is based on a single carbon fiber coated with WPI's NO-selective membrane. A detection limit of approximately 1 nM NO makes these electrodes ideal for use in tissues and microvessels.
The response of a 7μm NO sensor (ISO-NOP007) to successive additions of NO (100nM). Inset shows the linearity of the resulting calibration plot.
Simultaneous measurement of force (top trace) and changes of NO concentration (lower trace) in (A) the rat superior mesenteric artery relaxed with ACh and (B) a small human artery relaxed with ACh and SNAP. In this artery oxyhaemoglobin (oxyHb) partly reversed the increase in NO concentration with only a small change in force. [U. Simonsen, et al., J. Physiol., 1999, 516: 271-282.]
|Outside Diameter||7 µm||30 μm||30 µm|
|Available Length||2 mm||0.5 mm||2 mm|
|Response Time||< 3 seconds||< 3 seconds||< 3 seconds|
|Lowest Detection Limit/Range||0.5 nM||1 nM||1 nM|
|Nominal Sensitivity-New sensor||≥1 pA/nM||≥1.4 pA/nM||≥1.5 pA/nM|
|Poise Voltage||865 mV||865 mV||865 mV|
|Typical Quiescent Baseline Current, 25°C||300 pA||1000 pA||500 pA|
|Acceptable Baseline Range||200-1500 pA||150-3500 pA||500-5000 pA|
|Polarization Time||1+ hours||1+ hours||1+ hours|
Dantas, B. P. V, Ribeiro, T. P., Assis, V. L., Furtado, F. F., Assis, K. S., Alves, J. S., … Braga, V. A. (2014). Vasorelaxation induced by a new naphthoquinone-oxime is mediated by NO-sGC-cGMP pathway. Molecules (Basel, Switzerland), 19(7), 9773–9785. https://doi.org/10.3390/molecules19079773