Extracellular Amplifier with Active Probe

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A family of very low noise battery-operated extracellular amplifiers

  • Battery powered to eliminate line noise
  • High pass and low pass filtering
  • Single ended or differential operation
  • AC amplification only
  • Includes low-noise headstage
  • Variable output positioning
  • Constructed of high quality components to ensure minimal intrinsic (shot) noise
  • Portable
  • Rack mountable

The DAM80 Startup Kit includes: 2-CBL102, 5469, 2-13388, 3294, 2033, 2034, 2-2035


See the current Spec Sheet.

See what you need to know before you buy an amplifier.


  • Very low internal noise
  • Ultra quiet DC power supply ­— no AC required
  • Intrinsic low susceptibility to ground loops
  • Small footprint
  • Cost-effective
  • Electrostatic Discharge Protection!


  • Amplifying biopotentials from metal electrodes
  • Brain slice field stimulation
  • EAG (Electroantennogram)
  • ERG (Electroretinogram)


WPI’s DAM series amplifier’s are well known as a standard of the industry for extracellular potential amplification. These battery powered bio-amplifiers are designed with a compact chassis profile that enables the user to locate the unit closer to the preparation and thereby minimize long lead lengths which contribute to noise. Each amplifier is equipped with selectable high and low filters, and a position control to offset galvanic potentials which may develop during recording.

The startup kit (included) is shown in the image below.

DAM80 Startup Kit includes the pictured components.

Remote Active Headstage

DAM80, an AC amplifier only, features a very low noise headstage probe which can be mounted in micromanipulators for up-close cortical recording, for extracellular recording from high impedance glass or metal microelectrodes. The unit also provides a gated current for tissue marking. Microelectrode holder MEH7W-XX (sold separately) is recommended for glass microelectrodes.

Current Generation

The DAM80 is perfect for gated or manual current generation for histological marking, iontophoresis or cell stimulation. It includes a very low noise remote active headstage that is useful for very high impedance amplification utilizing glass or metal electrodes.


DAM series amplifiers can be used as standalone units on any tabletop, or use optional clamp-mounting hardware to locate them conveniently within the work area. Alternatively, a pair of amplifiers can be mounted into a standard equipment rack with a rack mount kit (#3484). A variety of hook up accessories are available to configure your application.

Feature Comparison Chart

  DAM50 DAM80
Input Mode AC/DC AC
Input Configuration Differential/Single Ended Differential
Gain Range 100-10,000 (AC)
10-1,000 (DC)
100 - 10,000 (AC)
High/Low Filters Yes Yes
Offset Position Control Yes Yes
Current Generator No Yes
Remote Active Headstage No Yes
Output Connection BNC 3.5 mm mini phone
Standard Input Connection unterminated wire Mini banana
Power Supply (2) 9V alkaline batteries (2) 9V alkaline batteries
INPUT IMPEDANCE 1012 Ω, common mode and differential
AC MODE NOISE 0.4 µV RMS (2uV p-p) 0.1-100 Hz
AC MODE NOISE 2.6 µV RMS (10uV p-p) 1Hz-10 kH
BANDWIDTH FILTER SETTINGS, AC Mode Low frequency, 0.1, 1, 10, 300 Hz
BANDWIDTH FILTER SETTINGS: AC Mode(DAM80) High frequency, 0.1, 1, 3, 10 kHz
OUTPUT CONNECTORS 3.5 mm MiniPhone connector on DAM80
BATTERY TEST Audible tone
CALIBRATOR SIGNAL 10 Hz square wave
POSITION Approximately 250 mV
CURRENT SOURCE:DAM80: DC Generator 0 to ±50 µA, variable
EXTERNAL COMMAND Input Voltage ±10 V commands
AC or DC current waveform ±50 µA max. amplitude @ 200 Ω
BATTERIES 2 x 9 V alkaline (included)
DIMENSIONS:DAM80 7 x 4 x 1.75 in. (17.8 x 10.2 x 4.4 cm)
SHIPPING WEIGHT 3.5 lb. (1.6 kg)

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More Choices:
  1. 9V Battery
    9V Battery
  2. Rechargeable 9V Battery
    Rechargeable 9V Battery
  3. Ground Wire for DAM80 Probe
    Ground Wire for DAM80 Probe
  4. Ringstand Mounting Kit
    Ringstand Mounting Kit
  5. Adapter Cable
    Adapter Cable
  6. BNC-TO-BNC CABLE, 6 '
  7. Adapter Electrode 0.031 for DAM80P
    Adapter Electrode 0.031 for DAM80P
  8. Uninsulated Mini Banana Plug
    Uninsulated Mini Banana Plug
  9. Red Insulated Mini Banana Plug
    Red Insulated Mini Banana Plug
  10. Black Insulated Mini Banana Plug
    Black Insulated Mini Banana Plug
  11. Electrode adapter for DAM probes
    Electrode adapter for DAM probes
  12. DAM Series, PM Series
    DAM Series, PM Series
  13. Manual Micromanipulator
    Manual Micromanipulator
    Multiple SKUs
  14. Ag/AgCl Electrode
    Ag/AgCl Electrode
    Multiple SKUs
  15. Tungsten Profile C, 127 mm long
    Tungsten Profile C, 127 mm long
    Multiple SKUs

Mutliple applications are available with a variety of options. Here you can see two setups.

Differential Applications for Metal Electrodes

In this setup, metal electrodes are used with a differential amplifier. In this setup, a DAM80 is shown, but you could easily substitute a DAM50 (with 5489), ISO-DAM8A (with 74040) or ISO-80.


Extracellular Applications Utilizing Glass Microelectrodes

For rare instances when using extracellular amplifiers with glass, you could use the setup shown below. In this setup, a DAM80 is shown, but you could easily substitute an ISO-DAM8A (with 74040) or ISO-80. Likewise, this setup shows the 2505 handle (1/4" - 6.3mm), but if you have a smaller micromanipulator, you may need the 5444 handle (3/16" - 4.8mm). In this illustration, MEH7W-10 is used, but any glass-size MEH7W could be used. (MEH7W-10 is 1.0mm glass, MEH7W-12 is 1.2mm glass, MEH7W-15 is 1.5mm glass and MEH7W-20 is 2.0mm glass.) EP2 is used for grounding in the illustration.

For single-ended applications, however, a 2033 wire adapter on the black connector socket can be connected to the 3294 cable. The tip used depends on your specific needs. In the illustration, TIP1TW1 was suggested. NOTE that the glass is not shown in the illustration below.



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