This website uses cookies to ensure you get the best experience on our website.
Read more
DAM50 Extracellular Amplifier
$1,647.00
Prices valid in USA, Canada, and PR only.
Order code
SYS-DAM50
Prices valid in USA, Canada, and PR only.
WPI’s DAM series amplifier’s are well known as a standard of the industry for extracellular potential amplification. These battery powered bio-amplifiers are designed with a compact chassis profile that enables you locate the unit closer to the preparation and thereby minimize long lead lengths which contribute to noise. Each amplifier is equipped with selectable high and low filters, and a position control to offset galvanic potentials which may develop during recording.
DAM series amplifiers can be used as stand-alone units on any tabletop or use optional clamp-mounting hardware to locate them conveniently within the work area. Alternatively, a pair of amplifiers can be mounted into a standard equipment rack with a rack mount kit (3484). A variety of hook up accessories are available to configure your application.
To learn more about our warranty options, click here.
Prices valid in USA, Canada, and PR only.
See the current Spec Sheet.
See what you need to know before you buy an amplifier.
A family of very low noise battery-operated amplifiers
Features
- Battery powered to eliminate line noise
- High pass and low pass filtering
- Single ended or differential operation
- DC/AC amplification
- Variable output positioning
- Constructed of high quality components to ensure minimal intrinsic (shot) noise
- Portable
- Rack mountable
- The DAM50 package now includes the 300647 shielded metal electrode cable and one shielded modular cable.
Benefits
- Very low internal noise
- Ultra quiet DC power supply — no AC required
- Intrinsic low susceptibility to ground loops
- Small footprint
- Cost-effective
- Electrostatic Discharge Protection!
- Premium Warranty Available
Applications
- Amplifying biopotentials from metal electrodes
- Brain slice field stimulation
- EAG (Electroantennogram)
- ERG (Electroretinogram)
Reducing Noise with Differential Amplification
Differential amplification is of great importance in bioelectric recording to reduce the ever present effect of noise interference from power line induction. A well designed differential amplifier will significantly diminish power line (mains) noise. It is most essential that the preparation be connected with an electrode to a good electrical ground as well as to the grounding wire of the DAM50 itself. This should have the effect of greatly reducing electrostatically induced potential. In addition to the preparation ground, two differential input connections must be made via appropriate electrodes applied to the recording site so as to optimally record a bioelectric potential difference.
Feature Comparison Chart
Type | DAM50 | DAM80 |
Input Mode | AC/DC | AC |
Input Configuration | Differential/Single Ended | Differential |
Gain Range | 100-10,000 (AC) 10-1,000 (DC) |
100 - 10,000 (AC) |
High/Low Filters | Yes | Yes |
Offset Position Control | Yes | Yes |
Current Generator | No | Yes |
Remote Active Headstage | No | Yes |
Output Connection | BNC | 3.5 mm mini phone |
Standard Input Connection | unterminated wire | Mini banana |
Power Supply | (2) 9V alkaline batteries | (2) 9V alkaline batteries |
Differential Applications for Metal Electrodes
The images below show two applications for metal electrodes.
In this first example, a sealed RC1T Ag/AgCl electrode pellet is wired to the amplifier cable. This also shows a differential configuration.
This second example shows an EP2 silver/silver chloride electrode pellet connected to the amplifier adaptor 5389. This shows a differential configuration. The EP2 is suitable for use in a mouse cranial application. To do so, it needs an extension wire 3294 to connect it to the 5389 adaptor.
SKU | SYS-DAM50 |
---|
Upsell Products
-
Tungsten Profile C, 127 mm long
As low as $192.00
INPUT IMPEDANCE | 1012 Ω, common mode and differential |
INPUT LEAKAGE CURRENT | 50 pA (typical) |
MAX. DC DIFFERENTIAL SIGNAL | ±2.5 V (DAM 50) |
GAIN | AC: 100x, 1000x, 10000x, DC: 10x, 100x, 1000x (DAM50) |
COMMON MODE REJECTION RATIO | 100dB @ 50/60 Hz |
INPUT CAPACITANCE | 20 pF |
AC MODE NOISE | 0.4 μV RMS (2uV p-p) 0.1-100 Hz |
AC MODE NOISE | 2.6 μV RMS (10uV p-p) 1 Hz-10 kH |
DC MODE NOISE (DAM50) | (DAM50) 7.5uV RMS (30uV p-p) 3-10 kHz |
BANDWIDTH FILTER SETTINGS:AC Mode | Low frequency, 0.1, 1, 10, 300 Hz |
BANDWIDTH FILTER SETTINGS: DC Mode(DAM50) | High frequency, 0.1, 1, 3, 10 kHz |
OUTPUT CONNECTORS | BNC |
OUTPUT VOLTAGE SWING | ±8 V |
OUTPUT IMPEDANCE | 470 Ω |
BATTERY TEST | Audible tone |
CALIBRATOR SIGNAL | 10 Hz square wave |
POSITION | Approximately 250 mV |
EXTERNAL COMMAND | Input Voltage ±10 V commands |
AC or DC current waveform | ±50μA max. amplitude @ 200 KΩ |
BATTERIES | 2 x 9 V alkaline (included) |
DIMENSIONS:DAM50 | 8 x 4 x 1.75 in. (20.3 x 10.2 x 4.4 cm) |
SHIPPING WEIGHT | 3.5 lb. (1.6 kg) |
The following bandwidth charts for the DAM50 show the response of the amplifier when various filters and gains are used. For larger images, click on the thumbnails below.
GAINS: This chart shows the standard 3dB frequency cutoff at maximum filter band pass.
FILTERS: Various low pass and high pass filters were applied at the AC x1000 gain setting to show the bandwidth of and actual DAM50 amplifier.
Kim, E. Y., & Virginia, W. (n.d.). Effect of Growth Hormone on Hippocampal Synaptic Function during Sleep Deprivation By.
full-text. (n.d.).
Dai, J., Brooks, D. I., & Sheinberg, D. L. (n.d.). Supplemental Information Optogenetic and Electrical Microstimulation Systematically Bias Visuospatial Choice in Primates.
Škorjanc, A., & Belušič, G. (n.d.). How We Teach: Classroom And Laboratory Research Projects Investigation of blood flow and the effect of vasoactive substances in cutaneous blood vessels of Xenopus laevis.
Liu, Y., Wang, Y., Zhu, G., Sun, J., Bi, X., & Baudry, M. (2016). A calpain-2 selective inhibitor enhances learning & memory by prolonging ERK activation. Neuropharmacology, 105, 471–477. http://doi.org/10.1016/j.neuropharm.2016.02.022
Ztaou, S., Maurice, N., Camon, J., Guiraudie-Capraz, G., Kerkerian-Le Goff, L., Beurrier, C., … Amalric, M. (2016). Involvement of Striatal Cholinergic Interneurons and M1 and M4 Muscarinic Receptors in Motor Symptoms of Parkinson’s Disease. Journal of Neuroscience, 36(35).
Kentish, S. S. J., Frisby, C. L., Kritas, S., Li, H., Hatzinikolas, G., O’Donnell, T. A., … Ahern, G. (2015). TRPV1 Channels and Gastric Vagal Afferent Signalling in Lean and High Fat Diet Induced Obese Mice. PloS One, 10(8), e0135892. http://doi.org/10.1371/journal.pone.0135892
Blauvelt, D. G., Sato, T. F., Wienisch, M., & Murthy, V. N. (2013). Distinct spatiotemporal activity in principal neurons of the mouse olfactory bulb in anesthetized and awake states. Frontiers in Neural Circuits, 7. http://doi.org/10.3389/fncir.2013.00046
Blaise, J. H. (2013). Long-term Potentiation of Perforant Pathway-dentate Gyrus Synapse in Freely Behaving Mice. Journal of Visualized Experiments, (81), e50642. http://doi.org/10.3791/50642
Wang, H., Siddharthan, V., Kesler, K. K., Hall, J. O., Motter, N. E., Julander, J. G., & Morrey, J. D. (2013). Fatal neurological respiratory insufficiency is common among viral encephalitides. The Journal of Infectious Diseases, 208(4), 573–83. http://doi.org/10.1093/infdis/jit186
Zhang, Q.-X., Lu, R.-W., Curcio, C. A., Yao, X.-C., DC., H., SE., N., … PN, D. (2012). In Vivo Confocal Intrinsic Optical Signal Identification of Localized Retinal Dysfunction. Investigative Opthalmology & Visual Science, 53(13), 8139. http://doi.org/10.1167/iovs.12-10732
Badsha, F., Kain, P., Prabhakar, S., Sundaram, S., Padinjat, R., Rodrigues, V., & Hasan, G. (2012). Mutants in Drosophila TRPC channels reduce olfactory sensitivity to carbon dioxide. PloS One, 7(11), e49848. http://doi.org/10.1371/journal.pone.0049848
Konow, N., Azizi, E., & Roberts, T. J. (2012). Muscle power attenuation by tendon during energy dissipation. Proceedings. Biological Sciences / The Royal Society, 279(1731), 1108–13. http://doi.org/10.1098/rspb.2011.1435
Chen, S., Mohajerani, M. H., Xie, Y., & Murphy, T. H. (2012). Optogenetic analysis of neuronal excitability during global ischemia reveals selective deficits in sensory processing following reperfusion in mouse cortex. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 32(39), 13510–9. http://doi.org/10.1523/JNEUROSCI.1439-12.2012
Morrey, J. D., Siddharthan, V., Wang, H., Hall, J. O., Motter, N. E., Skinner, R. D., & Skirpstunas, R. T. (2010). Neurological suppression of diaphragm electromyographs in hamsters infected with West Nile virus. Journal of Neurovirology, 16(4), 318–329. http://doi.org/10.3109/13550284.2010.501847
Brundage, C. M., & Taylor, B. E. (2010). Neuroplasticity of the central hypercapnic ventilatory response: teratogen-induced impairment and subsequent recovery during development. Developmental Neurobiology, 70(10), 726–35. http://doi.org/10.1002/dneu.20806
Kim, E., Grover, L. M., Bertolotti, D., & Green, T. L. (2010). Growth hormone rescues hippocampal synaptic function after sleep deprivation. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 298(6), R1588-96. http://doi.org/10.1152/ajpregu.00580.2009
Kavlie, R. G., Kernan, M. J., & Eberl, D. F. (2010). Hearing in Drosophila requires TilB, a conserved protein associated with ciliary motility. Genetics, 185(1), 177–88. http://doi.org/10.1534/genetics.110.114009
Lenti, L., Domoki, F., Gáspár, T., Snipes, J. A., Bari, F., & Busija, D. W. (2009). N-Methyl- d -Aspartate Induces Cortical Hyperemia through Cortical Spreading Depression-Dependent and -Independent Mechanisms in Rats. Microcirculation, 16(7), 629–639. http://doi.org/10.1080/10739680903131510
Su, C.-K., Ho, C.-M., Kuo, H.-H., Wen, Y.-C., & Chai, C.-Y. (2009). Sympathetic-correlated c-Fos expression in the neonatal rat spinal cord in vitro. Journal of Biomedical Science, 16(1), 44. http://doi.org/10.1186/1423-0127-16-44
Brundage, C. M., & Taylor, B. E. (2009). Timing and duration of developmental nicotine exposure contribute to attenuation of the tadpole hypercapnic neuroventilatory response. Developmental Neurobiology, 69(7), 451–61. http://doi.org/10.1002/dneu.20720
Orem, N. R., Xia, L., & Dolph, P. J. (2006). An essential role for endocytosis of rhodopsin through interaction of visual arrestin with the AP-2 adaptor. Journal of Cell Science, 119(Pt 15), 3141–8. http://doi.org/10.1242/jcs.03052
Markham, M. R., & Stoddard, P. K. (2005). Adrenocorticotropic hormone enhances the masculinity of an electric communication signal by modulating the waveform and timing of action potentials within individual cells. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 25(38), 8746–54. http://doi.org/10.1523/JNEUROSCI.2809-05.2005
Cartford, M. C. (2004). Cerebellar norepinephrine modulates learning of delay classical eyeblink conditioning: Evidence for post-synaptic signaling via PKA. Learning & Memory, 11(6), 732–737. http://doi.org/10.1101/lm.83104
Jonker, D. M., Vermeij, D. A. C., Edelbroek, P. M., Voskuyl, R. A., Piotrovsky, V. K., & Danhof, M. (2003). Pharmacodynamic Analysis of the Interaction between Tiagabine and Midazolam with an Allosteric Model That Incorporates Signal Transduction. Epilepsia, 44(3), 329–338. http://doi.org/10.1046/j.1528-1157.2003.37802.x
van den Pol, A. N., Ghosh, P. K., Liu, R., Li, Y., Aghajanian, G. K., & Gao, X.-B. (2002). Hypocretin (orexin) enhances neuron activity and cell synchrony in developing mouse GFP-expressing locus coeruleus. The Journal of Physiology, 541(1), 169–185. http://doi.org/10.1113/jphysiol.2002.017426
Ransom, C. B., Ransom, B. R., & Sontheimer, H. (2000). Activity-dependent extracellular K+ accumulation in rat optic nerve: the role of glial and axonal Na+ pumps. The Journal of Physiology, 522 Pt 3, 427–42. Retrieved from http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2269766&tool=pmcentrez&rendertype=abstract
Alloway, P. G., & Dolph, P. J. (1999). A role for the light-dependent phosphorylation of visual arrestin. Proceedings of the National Academy of Sciences, 96(11), 6072–6077. http://doi.org/10.1073/pnas.96.11.6072
Lipchik, G. L., Holroyd, K. A., France, C. R., Kvaal, S. A., Segal, D., Cordingley, G. E., … McCool, H. R. (1996). Central and peripheral mechanisms in chronic tension-type headache. Pain, 64(3), 467–75. Retrieved from http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2128054&tool=pmcentrez&rendertype=abstract
Knuckey, N. W., Palm, D., Primiano, M., Epstein, M. H., & Johanson, C. E. (1995). N-Acetylcysteine Enhances Hippocampal Neuronal Survival After Transient Forebrain Ischemia in Rats. Stroke, 26(2), 305–311. http://doi.org/10.1161/01.STR.26.2.305