Electrophysiology Research - Animal Physiology Equipment

From our early beginnings in 1967 working with Yale researchers, electrophysiology has been at the heart of our business. WPI amplifiers, stimulators and isolators are designed with quality components so you get a reliable, low-noise signal every time. Our time-tested designs give you affordable solutions for electrophysiology equipment, electrodes, data acquisition and accessories for applications like:

• Intracellular/Extracellular Recording

• Voltage Clamp for Ussing

• Stimulation and Isolation

• Optogenetics

• Digital Filtering

Electrophysiology is study of the flow of ions in living tissue, that is the electrical properties of cells and tissues, measuring voltage change of a biological entity from a single ion channel proteins to an organ (for example, heart). Micro electrodes (glass pipette filled with an electrolyte) are placed inside a single cell for intracellular measurement and near the surface of a cell or in a preparation for extracellular measurement.


WPI manufactures two-stage bio-amplifiers. Our low noise amplifiers for electrophysiology research use high quality components. (See our DAM series low noise amplifiers). Quality components minimize the noise in the first stage of amplification. This means that the dynamic range is retained throughout the amplification process. The end result is a lower signal to noise ratio, so you can distinguish your signal of interest.

Bioamplifiers for Electrophysiology research Amplifier Accessories
Extracellular Amplifiers
Intracellular Amplifiers
Transducer Amplifiers


WPI offers a broad variety of standard and custom single monopolar, concentric, and stereotrode designs in a variety of tip profile and metal combinations.

In addition, microelectrodes for electrophysiology research may be heat treated. Heat treated microelectrodes are ideal for penetrating tough membranes. They may also have a Kapton cladding to stiffen the shaft of the electrode and provide some insulation.

Nerve cuff electrodes for acute and chronic experiments are available in a variety of metals and configurations.

Reference electrodes and surface electrodes are also available.

Bipolar electrode Single, Bipolar & Concentric Electrodes
Nerve Cuff Electrodes
Reference Electrodes
Surface Electrodes


Electrophysiology Supplies

Electrophysiology Supplies

Power Supplies
Specialty Wire

Glass and Holders

Ag-AgCl Half-Cells
FluoroDish Cell Cultures
Glass Accessories
Glass Capillaries 
Microelectrode Holders 
Pre-Pulled Micropipettes  

Microforges, Pullers, Bevelers

 Microforge for fire polishing glass micropipettes Accessories

Specialty Instruments

Micropressure Specialty Instruments


WPI stimulators for electrophysiology research are constant current stimulators. These are preferred over constant voltage stimulators, because:

  • Current is the quantity that stimulates most excitable tissues.
  • Stimulating electrodes (and some tissues) tend to increase their resistance as stimulation progresses.

A constant current stimulator "senses" the resistance change and provides whatever voltage is needed to maintain delivery of current at the set rate.

Stimulus isolators isolate a given stimulus from ground. WPI isolators in the 300 and DLS series offer a compliance voltage (maximum output voltage) of 100V with very low noise.

Electrophysiology Stimulator equipment Stimulators
Stimulator Accessories
Stimulus Isolators

In the early 70's, WPI began building amplifiers, stimulators, isolators and other electrophysiology research equipment for Yale University researchers. We've come a long way in 50 years, but one thing hasn't changed. We still set the industry standard on how quality amplifiers should be built. When you require low noise amplifiers for making sensitive life science recordings, we can help.


More Information

Amplifier Selection Guide 

See why Low Noise Amplifiers Outperform Cheap Imitations. ()

Isolated Stimulation Explained

Metal Microelectrode Selection Guide