Flexible Hydrogen Sulfide Sensor

Order code

Low detection limit sensors to record in vitro

  • Hight selectivity and sensitivity to hydrogen sulfide with fast response time
  • Broad linearity
  • For use with Apollo1000, Apollo4000, TBR4100 and TBR1025
  • Requires cable 91580 (sold separate)
  • Package of 2


  • A dry sensor that works like a 2mm wet sensor
  • Response Time: ~5 s
  • Detection Limit: < 5 nM
  • Sensitivity: 1-4 pA/nM


  • Measure biological hydrogen sulfide in vivo or in vitro in tissues or biological media
  • Measure hydrogen sulfide released from drugs
  • Cell culture, cell suspensions, arteries, in vivo applications

About Hydrogen Sulfide

Although hydrogen sulfide is generally thought of in terms of a poisonous gas, it is endogenously produced in many mammalian tissues. It has been detected in micromolar amounts in blood and brain tissue. Hydrogen sulfide is reported as having a broad range of biological functions and although its potential to participate in cell signaling is clear, this biological role is not well understood. Hydrogen sulfide is strongly anagolous to nitric oxide because they share several physical and metabolic properties.

Hydrogen sulfide and oxygen

Like nitric oxide, hydrogen sulfide is a potent vascular signal that can mediate vasoconstriction or vasorelaxation depending on the oxygen level and tissue. In the rat aorta, hydrogen sulfide concentrations that mediate rapid constriction at oxygen level will cause rapid relaxation at lower oxygen levels.

Sensor details

The ISO-H2S-100 is a hydrogen sulfide sensor with a 100 µm diameter tip. It is designed like the dry microsensors, however, it works like a traditional 2 mm sensor. The sensor can be ordered in a variety of lengths from 2–5 mm. It incorporates WPI’s proprietary combination electrode technology in which the hydrogen sulfide-sensing element and separate reference electrode are encased within a single shielded sensor design.

The ISO-H2S-100 offers several advantages:

  • Requires no sleeves or filling solutions
  • Durable for long-term use, because of its platinum wire construction
  • Rapid response time
  • Broad linear range (Range is based on the length of the sensor tip)
Fiber diameter (µm) 100
Tip length (mm) 2-5
Response time (sec.) ~5
Lowest detection limit/Range (nM) < 5
Nominal Sensitivity - New sensor  (pA/nM) 1-4
Baseline drift (pA/min.) < 2

Chen, G., Yang, L., Zhong, L., Kutty, S., Wang, Y., Cui, K., … Fang, J. (2016). Delivery of Hydrogen Sulfide by Ultrasound Targeted Microbubble Destruction Attenuates Myocardial Ischemia-reperfusion Injury. Scientific Reports, 6, 30643. http://doi.org/10.1038/srep30643

Huang, P., Shen, Z., Liu, J., Huang, Y., Chen, S., Yu, W., … Jin, H. (2016). Hydrogen Sulfide Inhibits High-Salt Diet-Induced Renal Oxidative Stress and Kidney Injury in Dahl Rats. Oxidative Medicine and Cellular Longevity, 2016, 2807490. http://doi.org/10.1155/2016/2807490

Zhou, K., Gao, Q., Zheng, S., Pan, S., Li, P., Suo, K., … Fu, X. (n.d.). 7b-estradiol induces vasorelaxation by stimulating endothelial hydrogen sulfide release. http://doi.org/10.1093/molehr/gas044

Xie, L., Feng, H., Li, S., Meng, G., Liu, S., Tang, X., … Ji, Y. (2016). SIRT3 Mediates the Antioxidant Effect of Hydrogen Sulfide in Endothelial Cells. Antioxidants & Redox Signaling, 24(6), 329–343. http://doi.org/10.1089/ars.2015.6331 

Khan, S. N., Shaeib, F., Najafi, T., Kavdia, M., Gonik, B., Saed, G. M., … Abu-Soud, H. M. (2015). Diffused Intra-Oocyte Hydrogen Peroxide Activates Myeloperoxidase and Deteriorates Oocyte Quality. PloS One, 10(7), e0132388. http://doi.org/10.1371/journal.pone.0132388 

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