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Laboratory Equipment Blog

  1. WPI Equipment Used for MCAO on a Mouse
    July 01, 2014
    In this JoVE video you can observe as the researchers perform an intraluminal middle cerebral artery occlusion (MCAO) on a mouse. The MCAO model is the most frequent used model among experimental ischemic stroke models. WPI instruments used in this application include: SuperCut Iris scissor, straight 14218 Vannas micro-scissor, straight 14003 Dumont fine tip forceps 503290 Vessel clip
  2. Zebrafish Microinjection Technique from JoVE
    June 25, 2014
    Chiara Cianciolo Cosentino, at the University of Pittsburgh, describes how she uses intravenous microinjections of zebrafish larvae to study acute kidney injury in this JoVE video. You can also watch this video on JoVE. WPI equipment shown in this video includes: MMP Manual Microsyringe Pump PV820 Pneumatic PicoPump M3301 Manual Micromanipulator M10 Magnetic Stand 5052 Steel Base Plate
  3. REMS High Throughput TEER Robot Gets Software Upgrade
    May 30, 2014
    What is REMS? The REMS AutoSampler automates measurements of electrical resistance of transepithelial, transendothelial or Caco-2 cell membranes being grown to confluence on microporous filters of high throughput screening (HTS) 24- and 96-well microplates. It is a PC-controlled, tissue resistance measurement system that offers reproducibility, accuracy and flexibility for this kind of measurement. The ability of the REMS AutoSampler to precisely locate the electrode results in highly reproducible TEER measurements. TEER  measurements are stored in the computer as the electrode moves from one well to the next. The Windows-based
  4. 900A Micropressure System from WPI
    May 01, 2014
    The 900A is designed to measure hydrostatic pressure in small vessels and cells. Pressure ranges of -200 to +400 millimeters of mercury can be measured with stability and accuracy. The system's sensing element is an electrolyte-filled glass microelectrode with a tip diameter range of 2 to 5 microns. Pressures of electrolyte solutions are measured by maintaining a salt concentration gradient at the tip of the sensing electrode in dynamic equilibrium by applying an equal air pressure inside the microelectrode. The pressure reading appears on the front panel display and via the BNC recorder output. Because the piezo electric pressure controller uses external pressure and vacuum sources, pressures lower than -200 to greater than +400 mm Hg can be quickly and accurately measured at the microelectrode tip.
  5. Electronics Setup for Muscle Tester Platforms
    April 14, 2014
    Watch as we connect an SI-H single channel, motorized horizontal tissue bath with the necessary electronics. The same connections could be made for a Muscle Tester, a Horizontal Tissue Bath or an MKB Muscle Tester Platform. These muscle testers are used for running the full gamut of muscle physiology experiments. More Info
  6. REMS Robotic TEER Measurement for HTS
    April 08, 2014
    The REMS AutoSampler automates measurements of electrical resistance of transepithelial, transendothelial or Caco-2 cell membranes being grown to confluence on microporous filters of high throughput screening (HTS) 24- and 96-well microplates. It is a PC-controlled, tissue resistance measurement system that offers reproducibility, accuracy and flexibility for this kind of measurement. Automated measurement of tissue resistance in cell culture microplates provides the important advantages of speed, precision, decreased opportunity for contamination and the instant availability of measured resistance data on a computer. These measurements are useful in applications such as drug bioavailability studies and studies on the mechanisms of drug transport.
  7. SI-HTB Horizontal Tissue Bath Setup
    April 03, 2014
    Now, you can see the assembly of the World Precision Instruments SI-HTB2 Horizontal Tissue Bath. The  SI-HTB2 is used for muscle physiology research on small tissue samples. It is available with micrometers or motor assemblies. It is also available as 2-channel or 4-channel systems. More Info
  8. Common Tests Performed on Muscles Using SI-H Systems
    February 13, 2014
    Length Change Tests (No Force Feedback Required) Tests Components Test Description Parameter Determined Muscle Types Slack SI-H Muscle Research System equipped with: Linear Motor and Motor Control Amplifier Position Commands from MDAC Software Isometric Force Developed at Initial Length → Quick Release to New Length →  Muscle Shortens with No Load →Force Increases as Muscle Slack Taken Up Unloaded Shortening Velocity Tetanized Skeletal Muscle Most Smooth Muscle All Skinned Muscles Constant Velocity Release Isometric Force (Fo
  9. How the SI-BAM21-LCB Amplifier Works
    February 13, 2014
    In a typical muscle physiology setup, a muscle is held by a force transducer. The force transducer is connected to the SI-BAM21-LCB. As the muscle contracts or releases, the transducer converts the force into an electrical current signal which is proportional to the force applied to the transducer. The SI-BAM21-LCB converts the current signal into a voltage signal that can be displayed on the screen of the recording device. Before initiating an experiment, the SI-BAM21-LCB must first be zeroed. This sets the baseline for measurements to follow. The output signal is buffered and multiplied by 1, 2, 5 or 10, depending on the Gain switch setting on the front panel of the amplifier
  10. Eliminating the Resonance Frequency with the Anti-Oscillation Unit
    February 13, 2014
    Every force transducer has a resonance frequency at which it vibrates. The SI-AOSUB allows you to locate that frequency and filter the signal to mitigate the noise of the resonance frequency. Since each force transducer is unique, the anti-oscillation unit must be calibrated for each force transducer. Likewise, the tissue mounting hardware affects the resonance frequency. Therefore, the system must be calibrated with the mounting hardware attached to the force transducer. The SI-AOSUB Anti Oscillation module operates in conjunction with the SI-BAM21-LCB module and the motor controller to actively cancel the force transducer’s natural harmonic resonance. This is critical when performing dynamic mu
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