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Laboratory Equipment Blog

  1. How To Select Electrodes For Making TEER Measurements
    November 28, 2018
    Selection of Electrodes for TEER Measurements Transepithelial electrical resistance (TEER), also referred as the transepithelial resistance (TER) is used to monitor cellular health. TEER is comprised of measurements of the transcellular pathway (i.e., resistance due to an individual cell) and paracellular pathway (i.e., resistance due to the formation of the cellular junctions). TEER is commonly used to monitor cellular confluence. TEER values can indicate changes in the cellular monolayer permeability, showing the monolayer barrier function of cells such as, endothelial (brain microvessel) and epithelial (alveolar, kidney, and intestinal) cells. High TEER values generally reflect tighter cellular monolayers or cellular junctions (Lewis 1996, Matter and Balda 2003, Denker and Sabath 2011). A few major benefits of WPI TEER measurement systems are described below. The TEER values (electrophysiological analysis) can be combined with other analysis methods to further understan
  2. Easily Measure Color Dissolved Organic Matter (CDOM)
    October 08, 2018
    What is CDOM? CDOM (Color Dissolved Organic Matter) is organic matter whose optical properties are measurable using WPI’s LWCC (Liquid Waveguide Capillary Cell). CDOM occurs naturally in water systems and is derived from organic tannins. CDOM concentration depends on the location where samples are taken, with coastal waters showing higher CDOM concentrations compared to open-ocean waters. In addition, CDOM absorption depends on open-ocean water depth. Why is the study of CDOM levels important? CDOM is naturally occurring but the environment can influence the level of CDOM in water particles. Measuring the level of CDOM is important because CDOM can have a big effect from fresh to oceanic environments. For example, a higher concentration of CDOM in water particles reduces photosynthesis and negatively affects the food chain.
  3. WPI Awards Prize to The Zebrafish Network Winner
    October 08, 2018
    Jonas de Jesus, from WPI Brasil visit the winner of a contest to name a mascot for the Zebrafish Network. Jonas presented the winner with a surgical kit for zebrafish research. The project "The Zebrafish Network" is a result of the partnership of the Center for Toxins, Immune Response and Cell Signaling (CeTICS) of the Butantan Institute, and aims to promote communication and integration, as well as foster collaborations between researchers studying the fish "Paulistinha ", Which has been used for many scientific studies because of its genetic similarity with humans (70%). "The idea is that everyone who belongs to the network can divulge their work, interact with other researchers and inform about what is happening, such as publication of articles, lectures and congresses on the subject," explains Mônica Lopes , director of the Special
  4. Get a Clean Consistent Cut Every Time with Biopsy Punches
    August 22, 2018
    Clean, Consistent Cut Every Time When you need to quickly take minimally invasive, small samples, the biopsy punch is an easy choice. The biopsy punch is a hand held, pencil-shaped instrument with a slender, pencil-like body. It is lightweight with a hollow, circular, stainless steel, cutting tip. In 1887 Edward Lawrence Keyes, the first president of the American Association of Genitourinary Surgeons, was the first doctor who documented the importance of using the biopsy punch for dermatological diagnostics. He observed that the skin tissue samples can be obtained without complications, minimal bleeding and no need for suturing. Uses for Biopsy Punches Punches are not solely used in dermatology. Biopsy punches are also designed for therapeutics
  5. Using the 900A Micropressure System for Measuring Pressure in Small Blood Vessels and Cells
    July 16, 2018
    This 900A video series of 6 videos is designed to help familiarize you with the basic operation of the 900A Micropressure System. The 900A was designed for measuring pressures in kidney tubules, and it has many applications. It has recently been used for measuring ventricular blood pressure in larval fish. We suggest that you become familiar with the information in the instruction manual and the parts and techniques you need to operate the system effectively. Please read the manual and watch these videos prior to setting up and testing your 900A Micropressure System.  Instrument Description The 900A Micropressure System is designed to measure pressures from –200 to +400 mmHg in s
  6. How Do I Select Appropriate Surgical Instruments for My Application?
    March 13, 2018
    When you are selecting surgical instruments for a procedure, here are a few key points to consider What procedure are you performing? Published research papers usually indicate which instruments other researchers have used for similar procedures. The correct surgical instrument for a particular procedure makes a difference on the outcome of that technique. What is the size of your subject? An instrument that is perfect for a 200­–300 g rat (about 22–25 cm long) may not be the best choice for a neo-natal mouse of about 15 g (about 1–2.5 cm long). How often will the instrument be used? If you perform more than 100 cuts per day, a pair of titanium scissors or a pair of scissors with tungsten carbide inserts would be worth considering. They stay sharp longer.
  7. Replacing the Gasket in a Nanoliter2010
    February 13, 2018
    In this video you'll see how to replace the gasket in a Nanoliter2010.    More Info If you have questions, contact us at 866.606.1974 (US Toll Free) or at wpi@wpiinc.com. To request a formal quote, please email us at quotes@wpiinc.com.
  8. Absorbance Detection
    June 27, 2017
    Absorption of light correlates to the energy of a photon that is taken-up by electrons of the substance atom. The electromagnetic energy is transformed into internal energy of the absorbent substance. The absorbance of a substance quantifies how much of the incident light is absorbed by it (instead of being reflected or refracted). Precise measurements of the absorbance at many wavelengths allow the identification of a substance via absorption spectroscopy, where a sample is illuminated from one side, and the intensity of the light that exits from the sample in every direction is measured (see Fig. 1). A few examples of absorption are ultraviolet–visible (UV-Vis) spectroscopy or infrared (IR) spectroscopy.
  9. Using the Biofluorometer with Muscle Physiology Research systems
    June 27, 2017
    The use of fluorescence for sensing and imaging of the cellular signaling pathways has emerged as an indispensable tool in modern physiology, providing dynamic information of quantity and localization of the molecules of interest. Using appropriate indicator dyes, molecules alter their fluorescent characteristics in response to ion binding or membrane integration, so that the optical signal from the indicator can be measured to monitor the amplitude and the time course of various metal ions like Na+, K+, Mg2+ and Ca2+, as well as pH and membrane potential, in cellular compartments. A specific target molecule like Ca2+ is responsible for many physiological functions, such as neurotransmitter release, fertilization and ion channel functions. Studying the cellular channel functions is directly related to the transient increase in the myoplasmic free calcium concentration (Δ[Ca2+
  10. Detection of organic compounds in water analysis
    June 27, 2017
    Absorption of light correlates to the energy of a photon that is taken-up by electrons of the substance atom. The electromagnetic energy is transformed into internal energy of the absorbent substance. The absorbance of a substance quantifies how much of the incident light is absorbed by it (instead of being reflected or refracted). Precise measurements of the absorbance at many wavelengths allow the identification of a substance via absorption spectroscopy, where a sample is illuminated from one side, and the intensity of the light that exits from the sample in every direction is measured (see Fig. 1). A few examples of absorption are ultraviolet–visible (UV-Vis) spectroscopy or infrared (IR) spectroscopy. Fig 1. Concept of absorbance spectroscopy using white light and o
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