Electrophysiology

Electrophysiology

From our early beginnings in 1967 working with Yale researchers, electrophysiology has been at the heart of our business. WPI amplifiers, stimulators and isolators are designed with quality components so you get a reliable, low-noise signal every time. Our time-tested designs give you affordable solutions for electrophysiology equipment, electrodes, data acquisition and accessories for applications like:

• Intracellular/Extracellular Recording

• Voltage Clamp for Ussing

• Stimulation and Isolation

• Optogenetics

• Digital Filtering

Electrophysiology is study of the flow of ions in living tissue, that is the electrical properties of cells and tissues, measuring voltage change of a biological entity from a single ion channel proteins to an organ (for example, heart). Micro electrodes (glass pipette filled with an electrolyte) are placed inside a single cell for intracellular measurement and near the surface of a cell or in a preparation for extracellular measurement. Our newest product (Cardiophys ECG) is designed for cardiac electrophysiology and measures ECG in laboratory models as small as 2-cell zebrafish.

Researchers count on WPI for tried and true electrophysiology lab equipment.

  1. Amplifiers, Electrometers
    An amplifier, in simplest terms, is an electronic device that magnifies an input signal. In this case, the amplifier magnifies the small voltage changes in cells or tissues. Not all amplifiers are created equal. The way an amplifier is designed to handle the intrinsic noise of an electronic device and the bandwidth limitations of the amplifier greatly affects the quality and sustainability of the final output signal. WPI has been designing and building amplifiers since 1967. Quality components is the key to our faithful reproduction of an input signal. WPI offers intracellular amplifiers for measurements inside a single cell, extracellular amplifiers for measurement in interstitial fluid (outside a cell), transducer amplifiers for pressure, force displacement, temperature measurements and more. The purchase of a low-noise amplifier pays dividends in the end. WPI’s amplifiers were engineered for the bio-medical researcher. While 20-30μV of noise is common in bio-amplifiers, WPI’s DAM series amplifiers generate 0.4μV RMS (root mean squared) at 0.1-100Hz. (That’s equal to about 2μV peak to peak.) The chart below compares WPI’s bio-amplifiers.An amplifier, in simplest terms, is an electronic device that magnifies an input signal. In this case, the amplifier magnifies the small voltage changes in cells or tissues. Not all amplifiers are created equal. The way an amplifier is designed to handle the intrinsic noise of an electronic device and the bandwidth limitations of the amplifier greatly affects the quality and sustainability of the final output signal. WPI has been designing and building amplifiers since 1967. Quality components is the key to our faithful reproduction of an input signal. WPI offers intracellular amplifiers for measurements inside a single cell, extracellular amplifiers for measurement in interstitial fluid (outside a cell), transducer amplifiers for pressure, force displacement, temperature measurements and more.
  2. Cardiovascular
    World Precision Instruments is a global leader in the design, manufacture and supply of Physiology research instruments. In business for more than 50 years, we have thousands of citations in notable peer-reviewed publications. Assessment of cardiac physiology is integral for studies that: Examine the effects of therapeutic interventions Experimentally induce pathology Describe phenotypes linked to gene and molecular variants The heart generates its own electrical signal, which can be measured using the electrocardiogram (ECG). The ECG detects the extracellular voltage change that is produced as heart cells depolarize prior to contraction. As the signal moves through the heart in succession during each heartbeat, data collected from an ECG can inform on heart rate, ahrrythmia, chamber defects, channel pathologies and more. When you need highly versatile laboratory equipment for monitoring cardiovascular activity of a wide spectra of animals – as small as a zebrafish embryo to animals as large as an alligator – consider WPI.
  3. Single, Bipolar & Concentric Electrodes, Nerve Cuff
    WPI offers a broad variety of standard and custom single monopolar, concentric, and stereotrode designs in a variety of tip profile and metal combinations. Some of these electrodes are also available with Rhodes style tips. WPI offers a large variety of electrodes. For more informations, see FAQs about Metal Microelectrodes
  4. Electrophysiology Supplies
    These accessories (cables, connectors, footswitches, power supplies and specialty wire) are commonly used in electrophysiology applications.
  5. Specialty Instruments
    If you are looking for specialized laboratory equipment for electrophysiology, let us know. From low pass filters to micropressure systems, we have an interesting variety.
  6. Stimulators
    WPI stimulators for electrophysiology research are constant current stimulators. These are preferred over constant voltage stimulators, because: Current is the quantity that stimulates most excitable tissues. Stimulating electrodes (and some tissues) tend to increase their resistance as stimulation progresses. A constant current stimulator "senses" the resistance change and provides whatever voltage is needed to maintain delivery of current at the set rate. Stimulus isolators isolate a given stimulus from ground. WPI isolators in the 300 and DLS series offer a compliance voltage (maximum output voltage) of 100V with very low noise
  7. Stimulator Accessories
    For Electrophysiology equipment and accessories you can count on WPI. We've been building systems and components since the 1970s.
  8. Stimulus Isolators
    WPI offers a range of isolators and stimulators. Use the stimulus isolator comparison chart below to find the components that are compatible. For a better understanding for stimulus isolation, see Isolated Stimulation Explained.

In the early 70's, WPI began building amplifiers, stimulators, isolators and other electrophysiology research equipment for Yale University researchers. We've come a long way in 50 years, but one thing hasn't changed. We still set the industry standard on how quality amplifiers should be built. When you require low noise amplifiers for making sensitive life science recordings, we can help.

 

More Information

Amplifier Selection Guide 
Low Noise Amplifiers Outperform Cheap Imitations ()
Isolated Stimulation Explained
Metal Microelectrode Selection Guide

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