Although hydrogen sulfide (H2S) is generally thought of in terms of a poisonous gas, it is endogenously produced in many mammalian tissues. It has been detected in micromolar amounts in blood and brain tissue. Hydrogen sulfide is reported as having a broad range of biological functions and although its potential to participate in cell signaling is clear, this biological role is not well understood. H2S is strongly anagolous to nitric oxide (NO), because they share several physical and metabolic properties.
Like NO, H2S is a potent vascular signal that can mediate vasoconstriction or vasorelaxation depending on the O2 level and tissue. In the rat aorta, H2S concentrations that mediate rapid constriction at one O2 level will cause rapid relaxation at lower O2 levels. The ISO-H2S-2 sensor is a low detection limit sensor that works with WPI'sTBR4100 and TBR1025 free radical analyzers to record H2S in vitro. It is the only sensor available that measures H2S.