NanoFil™ Sub-microliter injection system for small animal research |
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| Selecting the correct tip for your application | ||||
| The replaceable needles used with the NanoFil are available with either blunt or beveled tips. The blunt tip is used for injection into soft tissue and when a uniform solution distribution is needed. The beveled style is used for applications that involve the penetration of a tough tissue. One of the main factors that limit the resolution and accuracy of conventional micro syringes to the upper tens of nanoliters range is diffusion in the large tip ID. When the tip ID is equal or larger than 100 micron, the error caused by tip diffusion is in the nanoliter range level ( (100 micron)^3 = 1 nanoliter ). With a 36 gauge needle installed on the NanoFil, the error caused by diffusion will be reduced to the sub nanoliter level, making accurate injection of a nanoliter possible. All of WPI’s beveled tips have a unique 25 degree tri-surface bevel that is optimized for microinjection. A 10 degree single-surface beveled tip penetrates better than one with a 25 degree angle, however the distance between the upper opening to the tip is longer. As a result, it requires a deeper penetration of the tip to achieve the same level of liquid delivery. Deeper penetration means more tissue damage. WPI’s unique 25 degree beveled tip solves this problem with two extra beveled surfaces. The tip of a single surface beveled tip is actually a blade instead of a point. It dulls very quickly. In contrast, the tri-surfaced tip has a real point. It not only penetrates much better but is also much more durable. Our tests show that our 33 gauge, 25 degree beveled tip penetrates easier and lasts longer than other manufacturer’s 33 gauge, 10 degree single beveled tips. With a 35 gauge tri-surface beveled tip, the resistance to the penetration becomes even less. Each of our tips undergo a penetration test before leaving the factory to guarantee the best results for our customers. |
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