| LOW TOXICITY 5-MINUTE ADHESIVES FOR LIVE TISSUES | ||||||||||||||||||||||||||||||||||||||||||
 
The properties of this adhesive make it exceptionally useful for neuroscience applications, peripheral nerve studies and similar biomedical applications. These new silicone elastomers also eliminate the mess and time involved in pre-mixing other commonly used formulations (such as Wacker SilGel‘ and Sylgard‘). Each silicone elastomer is packaged in a double barrel syringe and is automatically mixed when pressed out of the mixer tip provided. It can then be applied directly to the tissue without further mixing. The curing time of these silicones is short, reliable and reproducible thus eliminating potential costly guesswork when using other tissue adhesives. Furthermore, the curing process does not produce heat, which can otherwise cause tissue damage. WPI’s silicone elastomers are much less toxic than dental silicone because they contain no surfactant additives. WPI’s silicone elastomers are based on recently developed vinyl terminated siloxane and platinum complex catalysts. They exhibit exceptional low toxicity before, during and after curing. The traditional RTV silicone systems produce either acetic acid or alcohol during condensation; these compounds are toxic to living cells. In contrast, the only by-product of condensation from WPI’s elastomers is a small amount of hydrogen gas, which was shown not to cause any effect on nerve activity in highly sensitive peripheral nerves. Both elastomers cure on contact with the tissue. Currently, WPI provides rapid-curing silicone elastomers in two different formulas: Kwik-Sil™ is a translucent silicone elastomer adhesive with medium viscosity. It has good adhesion and mechanical property (tear strength and elongation). The very short curing time (approx. 1 minute) make it especially useful for moving preparations. Kwik-Cast™ is a very low viscosity silicone elastomer sealant. It is able to fill small spaces around nerves and creates a continuous mass ensuring long-term recording stability. Kwik-Cast is color-coded so mixing is foolproof. It can be applied and cured underneath mineral oil. The slight longer curing time (approx. 3 minutes) makes it more suitable for stationary preparations and in vitro tissue studies. |
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| KWIK-SIL Silicone Adhesive Compound (two 5ml syringes and 10 Mixing tips included) $85 |
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KWIK-CAST Silicone Casting Compound (two 5ml syringes and 10 Mixing tips included) $75 | |
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| Kwik-Sil™ is a trans lucent silicone adhesive with medium viscosity. This product has been developed for chronic peripheral nerve studies such as anterograde tracing with fluorescent indicator or electrode recording. Good adhesion and mechanical property (tear strength and elongation) allow days of study without breaking off the bonding. | Kwik-Cast™ is a very low viscosity silicone sealant developed to embed peripheral nerves with electrodes for acute multifiber recordings. It exhibits vast improvement over dental impression materials. It is able to fill small spaces around the nerve and create one continuous mass ensuring long term recording stability. For neurophysiological applications, it is much less toxic than dental silicone because it contains no surfactant additives. Kwik-Cast is color-coded so mixing is foolproof. It can be applied and cured underneath mineral oil. After recording, electrodes can be easily recovered. |
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| MSDS Information | ||||||||||||||||||||||||||||||||||||||||||
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