S-Nitroso-N-acetyl-D,L-penicillamine

SNAP is a stable green crystalline S-nitrosothiol compound that mimics the action of nitric oxide in vivo. It has vasodilatory properties and has been shown to relax isolated bovine coronary artery rings by activating soluble granulate cyclase. This reagent also actuates apoptosis in mouse thymocytes and has been accounted for reversible inactivation of protein Kinase C. SNAP can be used for calibration of all WPI NO sensors.

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M.W. 220.2 Purity > 98% by NMR or TLC
REFERENCES


Askew, S.C., et al. 1995. Bioorg. Med. Chem. 3, 1.
Fehsel, K., et al. 1995. J. Immunol. 155, 2858.


Gopalakrishna, R., et al. 1993. J. Biol. Chem. 268, 27180.
Southam, E., and Garthwaite, J. 1991. Neurosci. Lett. 130, 107.


Henry, P.J., et al. 1989. J. Pharmacol. Exp. Therap. 248, 762.


SNAP50 SNAP, 50 mg vial
SNAP100 SNAP, 100 mg vial
SNAP500 SNAP, 500 mg vial