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Isolated Working Heart (Langendorff & Neely) System

Order # SI-LANGWH

Isolated Working Heart (Langendorff & Neely) System
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  • For use on small mammalian hearts (mouse, rat, guinea pig, hamster or rabbit)
  • Working and non-working options in same unit
  • Easy removal of tissue for biochemical investigation
  • Constant pressure/Constant flow



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The SI-LANGWH isolated working heart system was developed for in vitro measurements of the mechanical activity and work performed by hearts from small animals according to the methods devised by J. R. Neely, et al. This system is designed with a combination of features from both the classic Langendorff (non-working) and the Neely (working) systems. This system includes a stainless steel sink, a small reeling pump and specially designed two-way Teflon taps.

  • For use on small  mammalian hearts (mouse, rat, guinea pig, hamster and rabbit)
  • Working (Neely) and nonworking (Langendorff) options in the same device
  • Control of the left ventricular diastolic pressure (LVDP), coronary flow and cardiac output by variation of the left atrial filling pressure and the hydrostatic pressure in the aorta
  • Measurement of the heart rate, atrial and ventricular pressure and cardiac output
  • Ports for drug administration
  • Pacing of the heart is possible
  • Special ECG sensor available
  • Tissue easily removed for biochemical investigations

 

Width 
600mm
Length 
800mm
Height 
2550mm
Weight  80kg

This system includes:

 Qty Component
Description
Comments
1
Isolated Perfused Organ System

Includes:

  • Table with base plate, shelf, and sink
  • Console
  • Perfusion buffer column (1)
  • Glass overflow tube
  • Lung column
  • Elastic chamber (2)
  • Teflon Tap valve
  • Heart suspension unit with cannulas
  • Heart chamber
  • Pressure sensors (2)
  • Oxygenation bubbler set
  • Oxygenation pressure equalizer set
  • After load regulation adapter
  • Basic analog flow meter
  • Silicon tubing set, cables and accessories
 
1
Peristaltic pumps  PERIPRO-2HS Peristar Pro 2-channel For filling buffer reservoirs
PERIPRO-4HS Peristar Pro 4-channel
For lung and coronary return circuits
1 Circulating Water Bath

 
2 Pressure transducers with cables
 Perfusion (Aortic) and Left Ventricular/Atrial Pressures
Requires two channels of the Bridge/Transducer Amplifier
1
Latex Pressure Balloons
   
 balloons.jpg
There are no references for this product.
To place an order for this product, please contact the appropriate WPI office or distributor.

Customers from North America can order direct from our corporate office:
World Precision Instruments
175 Sarasota Center Boulevard
Sarasota, FL 34240-9258
  • Phone or Fax
    Toll-free: 866-606-1974 Tel: 941-371-1003 Fax: 941-377-5428
  • Our Customer Service Representatives are available 8am - 6pm EST.
  • Online Store
    Many of our products are available for purchase through our online store. At this time we can only accept orders from the U.S. through the online store.
  • Want instant pricing? Order a free catalog here
International customers, please see our office and distributor contact information list.

Optional Components

 Part Number
Description Comments
SI-SEN12AM4E-U    
Manipulator with removable head (Unipolar electrode)
Select unipolar for stimulating/pacing, or bipolar for recording signals or surface potentials
SI-SEN12AM4E-B    
Manipulator with removable head (Bipolar electrodes)
SI-SEN07RTH2   
Temperature probe for measuring the temperature of the buffer entering or exiting the heart. Requires amplifier
 Attach to a port on the heart suspension unit. Requires an amplifier
SI-SEN13MAP   
12-electrode sensor for recording MAP (ECG) from different positions around the heart
 Requires multi-channel amplifier for recording signals from the 12 leads in the sensor
LABTRAX4-24T Lab Trax Data Recording

Possible signals to record:

  • Perfusion (Aortic) pressure
  • Left ventricular/atrial pressure
  • Temperature
  • Flow
  • ECG
  • Muscle force
WPI-118 Digital Data Recorder
  Transonic Transit Time Modular Flow Meter, inline flow sensor and meter  Connect the output of the flow meter directly to the data recording system
BRIDGE8 Transducer Amplifier Module  Needed for recording from the pressure transducers and temperature sensor if WPI-118 is used
74030 ISDB Chassis and Power Supply Required for BRIDGE8 modules
TBM4M Transbridge Transducer Amplifier Needed for recording fromthe pressure transducers and temperature sensor
SI-KG20 KG Force Transducer
 KG20 transduers only work with the BAM21E transducer amplifier
SI-BAM21E Bridge Amplifier Only controls KG20 transducers
DAM 50 Single channel bio-potential amplifier Record surface potential (composite ECG) from the heart with ball-mounted bipolar electrodes
A385 High Current Isolator For stimulating or pacing the heart
No application notes are available for this product at this time.
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Last Updated: Friday, 25 May 2012 13:14


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