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The Compact Langendorff system was developed for in vitro investigations of the hearts of small animals in constant pressure and/or flow modes. Even though the system occupies a small amount of bench space, it contains all the features of non-working (Langendorff) and working perfusion systems in a single, compact, thermostaticallycontrolledunit.
- Fluid columns are replaced by electronically adjusted flow control to keep the pressure at desired values from 0–500mmHg
- Langendorff and working heart perfusion modes
- Real-time calcium imaging available
- Compact, all-in-one unit thermostatically controlled to 0.1°C degree
- Four 500mL saline reservoirs which can easily be connected to create 2L and 1L volumes
- Special heart suspension module
- Muscle action potential (MAP) sensors sized for mouse, rat, guinea-pig and rabbit hearts
- Capability to measure the following parameters: muscle action potentials (MAP), left ventricular pressure (LVP), perfusion pressure, coronary flow, buffer temperature, heart rate (HR), ECG, surface potentials, muscular tone and force with force-displacement method
- Capability of pacing and stimulation can be added
The system contains four perfusate reservoirs that can store 500mL of preheated and oxygenated buffer each. Through a system of valves, the reservoirs can be connected to create one large (2L), two medium (1L each) or four small (500mL) volumes. This flexibility allows you to test different doses of a drug consecutively, or combinations of drugs concurrently.
The system also has a unique heart suspension module that permits easy attachment of the heart to the system, as well as the concise placement of the heart within a 12-lead muscle action potential (MAP) sensor.
The integrated temperature control system lets you set the temperature in 0.1 °C degrees increments. Also, heat transfer between the device and the surrounding air is very low, establishing a stable environment for the heart preparations.
Real Time Calcium Imaging
If you're interested in calcium imaging, you no longer need a dedicated room to accommodate the 2.5m height of the standard Langendorff with columns. This ingenious Langendorff system was engineered using a pressure clamp apparatus to replace the bulky columns so that the entire system is small enough to fit into a dark box for imaging. Everything you need to begin calcium imaging is available now through SI-Heidelberg.
To place an order for this product, please contact the appropriate WPI office or distributor.
Customers from North America can order direct from our corporate office:
World Precision Instruments
175 Sarasota Center Boulevard
Sarasota, FL 34240-9258
- Phone or Fax
Toll-free: 866-606-1974 Tel: 941-371-1003 Fax: 941-377-5428
Our Customer Service Representatives are available 8am - 6pm EST.
- Online Store
Many of our products are available for purchase through our online store.
At this time we can only accept orders from the U.S. through the online store.
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