WPI’s Parallel Rail Stereotaxic Frame systems are heavy-duty research instruments for large laboratory animals such as cats, monkeys, and dogs. The solid large frame and superior rigidity ensure the precise alignment of animals for Stereotaxic surgery, injection, and recording. The system can adopt up to four manipulators with 100-micron resolution on each axis. Each manipulator can smoothly moved to and locked at any location on both parallel rails in an arrange of 20 cm.