Electrochemical detection of oxidizable compounds
Carbon fiber microelectrodes have been used in both the detection of
oxidizable compounds (Gonon, et al., 1978; Cahill and Wightman, 1995)
and extracellular single-unit recording (Armstrong-James and Millar,
1979). WPI™s ultra-sensitive and low-noise carbon fiber (CF) electrodes
can be applied, with our Micro-C Potentiostat or similar instruments,
in the electrochemical detection of catecholamines (epinephrine,
norepinephrine and dopamine), indolamines (serotonin, 5-HT or
melatonin), Fe (II) and other oxidizable compounds.
Fig. 1-Excellent linearity in response of carbon fiber electrode (CF30-500) to dopamine recorded on a MicroC. Courtesy: Drs. D Yeomans and X.-T. Wang, University of Illinis at Chicago.
Applications
CF electrodes (diameter of 10 or 30 um) respond with an excellent
linearity to the oxidizable compounds and can detect the compounds as
low as 0.2 nM. The shorter (25-100 um) CF electrodes are suitable for
in vivo amperometric and voltammetric measurements. When used with the
Micro-C Potentiostat, these CF electrodes can be activated and renewed
in sensitivity for multiple use. The selective detection of
catecholamines can be achieved with our Nafion-coated CF electrodes.
For selective detection of 5-HT, please contact WPI
for more information.
Fig.
2-Extracellular recording using a carbon electrode in CA1 region of the
hippocampus in an anesthetized rat shows ultra-low noise ( ≤5μV).
Courtesy: Dr. Carolyn Harley of Memorial University, Newfoundland,
Canada.
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