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MicroFluidics: Lab-on-chip to Drug Discovery Print E-mail
Written by Lisa J Fulghum   

MFCS SystemFor control of fluids in the nanoliter and microliter ranges, the FL-MFCS (Fluigent Microfluidics Control System) is the system of choice. It eliminates the hysteresis, long equilibrium times and pulsing problems that plague standard peristaltic and syringe pumps in the low volume ranges. Three systems are available, but the systems are completely customizable and easily upgradable at any time.  On this website, you will find several representative systems, but each system is made to order with your custom configuration. This article covers the options available with the Fluigent system.

Applications for microfluidics include liquid chromatography, lab-on-chip and µTAS systems, drug delivery, life sciences, quality testing and rheology studies.

Building Your Microfluidic System

  1. The first step in choosing your system, is to determine which pressure ranges you need.
  2. Then, decide how many channels you need. The pressure ranges and number of channels determines which of the three customizable platforms you need (Low pressure, high pressure or negative pressure).
    NOTE: You choose the number of channels and the pressure range for each channel. These systems can be easily upgraded any time to add additional channels or pressure ranges.
  3. Finally, choose a fluid connection accessory. The three options include the FL-FLOWELL, FL-FLUIWELL and the FL-ELECTROWELL.
You can contact a representative to ask questions or request a quote by calling 866.606.1974 (US only) or emailing This e-mail address is being protected from spam bots, you need JavaScript enabled to view it .

Three Customizable Platforms

  • Low Pressure - FL-MFCS-FLEX 
    • Pressure channels: 0 to 25 mbar, 0 to 69 mbar, 0 to 345 mbar or 0 to 1000 mbar.
    • 1 to 8 pressure channels, with mixed configurations (channels of differing pressure ranges) available
    • Highest precision and stability
  • High Pressure - FL-MFCS-100 High Pressure System
    • Pressure channels from 0 to 7 bar (0-100 PSI)
    • 1 to 4 pressure channels
    • Highest dynamic pressure range and excellent precision and stability
  • Negative (Vacuum) Pressure - FL-MFCS-VAC Vacuum System
    • Vacuum microfluidic pressure pump for withdrawing fluids
    • Vacuum pressure channels: 0 to -25 mbar, 0 to -69 mbar or 0 to -345 mbar
    • 1 to 8 pressure channels
    • Mixed configuration available (with channels of differing pressure ranges)
    • Highest precision and stability.

Fluid Connection Accessories

After selecting your system options and configuration, you can choose one of three fluid connection appliances.

  • FlowellFL-FLOWELL - The Flowell system includes three flow meters, four reservoirs that can be pressurized and a computer connection.Three mass flow meters with pressurized reservoirs of the Flowell system monitor the flow of liquid through the channels. A precise sensor with amplification capabilities is combined with the A/D converter and signal processor on a single CMOS chip. Reservoirs can be integrated directly on the chip or externally located. Using an adapted pneumatic setup, a Wheatstone bridge creates a pressure divider bridge to allow dynamic control of the pressure. You can optimize the system for precise measurements or for handling rapidly changing flows.
    • Simultaneous pressure control and real time flow rate monitoring : 0-7 μL/mn, 0-50 μL/mn or 1 mL/mn
    • Calibrated for aqueous solution and temperature compensated
    • High precision : ~ 0.1%
    • Instantaneous response time : < 200 ms
    • Can be monitored when either injecting or withdrawing fluids
    • Unique flow rate regulation option available
  • FL-FLUIWELL FLUIWELL
    • Easy microfluidic connection of up to four different fluids for your application
    • Available with high volume vials, allowing longer non-stop experiments
    • Easy pre-treatment of each fluid before transfer (compatible with autoclave, etc.)
    • Disposable and independent commercial vials for liquid, avoiding any cross contamination.
    • Available with 1 or 4-wells
  • FL-ELECTROWELL ELECTROWELL
    • Simultaneous electrical and pressure control of your flow
    • Up to 6000V potential difference
    • Four independent channels
    • Easy microfluidic connections
    • Delivered with platinum electrodes. Compatible with Cu, Ag, etc.

Understanding the System Part Numbers

A typical microfluidics system part number is FL-MF2C-25. 

  • FL-MF - Identifies the system as a microfluidics control system
  • 2C - Indicates the number of channels in the system. In this case, it's a 2 channel system.
  • 25 -  Specifies the pressure range of the system. Here, it is a 0-25mbar system
  • V - If a V follows the part number (FL-MF2C-25V), the system is a negative pressure (vacuum) system.
  • H - If an H follows the part number (FL-MF2C-7H), the system is a high pressure system. In this case, the 7 indicates a 0–7bar system.
If you have any questions regarding Microfluidic Systems or other WPI products, give us a call toll-free at 866.606.1974 or email us at This e-mail address is being protected from spam bots, you need JavaScript enabled to view it This e-mail address is being protected from spam bots, you need JavaScript enabled to view it .

 

Last Updated ( Thursday, 21 April 2011 )
 
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